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RNA Resource for Synthetic Lethal Screening of DNA Repair and

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
96583
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
N43OD201000077
Solicitation Year:
N/A
Solicitation Topic Code:
OPPNE
Solicitation Number:
N/A
Small Business Information
ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road SAN DIEGO, CA 92121-2910
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: RNA Resource for Synthetic Lethal Screening of DNA Repair and
Agency: HHS
Contract: N43OD201000077
Award Amount: $199,918.00
 

Abstract:

The objectives of this proposal are to develop gene silencing reagents, and to test/validate their use in  synthetic lethal screening of DNA damage signaling and repair pathways. Making such reagents available will provide the efficiency and convenience that cancer researchers currently need to find novel strategies and therapeutics against cancer.    DNA repair pathway genes have been shown to encode important factors in cancer biogenesis. Targeting different networks within this pathway may be a promising point of action for curing cancer. The proposed research can facilitate the efforts in finding such cures. The research plan includes a novel combination of a number of essential elements, for example, highly efficient construction of lentiviruses carrying shRNA and use of surrogate targets for gene silencing assays.

Principal Investigator:

Jiwu Wang
Small Business Information at Submission:

ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road SAN DIEGO, CA 92121-2910

EIN/Tax ID: 152220107
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No