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AUTOMATED CULTURE OF LYMPHOKINE-ACTIVATED KILLER CELLS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11148
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11148
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Endotronics Inc.
8500 Evergreen Blvd Coon Rapids, MN 55433
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: AUTOMATED CULTURE OF LYMPHOKINE-ACTIVATED KILLER CELLS
Agency: HHS
Contract: N/A
Award Amount: $48,965.00
 

Abstract:

ADOPTIVE CELLULAR IMMUNOTHERAPY HAS RECENTLY DEMONSTRATED ENORMOUS PROMISE AS A METASTATIC CANCER TREATMENT. DESPITE THIS PROMISE, LYMPHOKINE-ACTIVATED KILLER (LAK) CELL THERAPY HAS BEEN SEVERELY LIMITED BY THE PROHIBITIVE TASK OF IN VITRO IMMUNE CELL PROLIFERATION. RECENTLY, HOLLOW-FIBER MAMMALIAN CELL CULTURE INSTRUMENTATION HAS BEEN APPLIED TO LAK CELL CULTURE. THIS TECHNOLOGY GENERATEDLARGE NUMBERS OF CELLS THAT LED TO SUCCESSFUL SAFETY STUDIESON HUMAN PATIENTS. THE OBJECTIVE OF THE PHASE I RESEARCH IS TO BUILD ON THIS EXPERIENCE AND DEVELOP PROCESS CONTROL MECHANISMS AND SPECIFICATIONS FOR INSTRUMENTATION THAT FITS SCALE-UP REQUIREMENTS OF LAK CELL CULTURES. THE OVERALL PHASE II GOAL IS TO DEVELOP A COST-EFFECTIVE INSTRUMENT THAT AUTOMATES ALL CULTURE METHODOLOGY REQUIRED BY IMMUNE CELL THERAPEUTICS. AUTOMATED LARGE-SCALE CULTURE IN HOLLOW-FIBER BIOREACTORS INCORPORATES SEVERAL COMPUTERIZED PROCESS CONTROL SCHEMES THAT MAINTAIN CULTURES FOR SEVERAL MONTHS. PHASE I RESEARCHWILL BEGIN SPECIFIC PROCESS CONTROL DEVELOPMENT NEEDED TO SCALE UP AND OPTIMIZE THE LAK CELL CULTURE ENVIRONMENT. A LAK CELL-SPECIFIC INSTRUMENT WILL BE DEVELOPED IN PHASE II. THIS INSTRUMENT WILL MEET THE TECHNOLOGICAL AND ECONOMIC NEEDS OF COMMERCIAL APPLICATION, YET ENHANCE INDIVIDUAL IMMUNE CELL THERAPEUTICS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Endotronics Inc
8500 Evergreen Blvd Coon Rapids, MN 55433

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No