USA flag logo/image

An Official Website of the United States Government

Analysis Software to Characterize Myocardial Mechanics

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54024
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43HL068314-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Engineering Software Research & Development, Inc.
111 West Port Plaza Suite 825 St. Louis, MO 63146-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Analysis Software to Characterize Myocardial Mechanics
Agency: HHS
Contract: N/A
Award Amount: $99,917.00
 

Abstract:

A prototype for a Windows-based software system that will make it possible to employ advanced mathematical modeling techniques for the characterization of the mechanical properties of the myocardium for clinical applications will be developed. The existing software product StressCheck, based on the p-version of the finite element method, will provide the computational framework for this development. The Input of the program will be (1) multiple layer short-axis and long-axis MRI scans of the heart, with and without radio frequency tissue-tagging, and (2) non-invasively obtained, digitized carotid artery pulse pressure obtained at the bedside. This information will be compiled as MRI-based 3D geometrical data sets, 3D myocardial displacement data sets, and calibrated systolic loading data sets. The output from the system will provide two separate clinical solutions: (1) global left ventricular end- systolic stress calculation based upon a finite element solution utilizing patient-Specific left ventricular topological data and end-systolic loads, and (2) left ventricular regional strain characterization based upon regional determination of both quantified circumferential minimum principal strain and minimum principal strain vector determination at baseline (viability) and during low dose Dobutamine (viability) and high dose Dobutamine (ischemia) infusion. PROPOSED COMMERCIAL APPLICATIONS: The software product developed under this project will provide an advanced automated and unbiased tool for the evaluation of AM data for heart patients. It will be marketed worldwide by manufacturers of MM equipment.

Principal Investigator:

Ricardo L. Actis

Business Contact:


3149839649
SZABO@ERSD.COM
Small Business Information at Submission:

ENGINEERING SOFTWARE RESEARCH
AND DEVELOPMENT, INC. 10845 OLIVE BLVD, STE 170 ST. LOUIS, MO 63141

EIN/Tax ID: 431517896
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No