SBIR Phase I:Feasibility of a minimally-invasive biomaterial therapy for heart failure
This Small Business Innovation Research (SBIR) Phase I project will test the feasibility of delivering a biomaterial treatment for myocardial infarction (MI) and heart failure via catheter, thereby paving the way towards translation and commercialization. Despite recent advances in tissue engineering, heart failure post-MI continues to be the leading cause of death in the U.S. with end-stage heart failure patients still relying on donor hearts. Herein, the feasibility of delivering a regenerative matrix via catheter to the heart will be tested. The key objectives of this project are: 1) Demonstrate injection of the myocardial matrix through a catheter in a porcine MI model, and 2) Demonstrate gelation and targeted delivery of the myocardial matrix in a porcine MI model.
The broader/commercial impacts of this research are the development of a new minimally invasive therapy for treating the millions of patients that suffer a MI each year, and the drastic reduction in the cost of healthcare related to MI by preventing subsequent heart failure, which is currently estimated at $37.2 billion for indirect and direct costs in 2009. This product will have significant advantages over competing technologies including: 1) minimally invasive delivery, 2) no need for donor organ or cell collection, 3) no need for immunosuppressive therapies, 4) off-the-shelf available treatment, and 5) low cost. Moreover, this will be the first injectable regenerative biomaterial product for treating the millions of patients suffering from MI and heart failure.
Small Business Information at Submission:
3231 Hill St San Diego, CA 92106
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