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Integrated Expression and Process Monitoring System for Biomanufacturing

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: DAAD13-02-C-0046
Agency Tracking Number: C2-0097
Amount: $0.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
4100 Quakerbridge Road
Lawrenceville, NJ 08648
United States
DUNS: 361940406
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Robert Steffan
 Vice Pres., Technology De
 (609) 936-9300
 steffan@envirogen.com
Business Contact
 Mark Maten
Title: Chief Financial Officer
Phone: (609) 936-9300
Email: maten@envirogen.com
Research Institution
N/A
Abstract

"The goal of this Phase II SBIR project is to develop an improved process monitoring and control system for biomanufacturing. The completed system will include expression vectors that can be used to produce and secrete commercially useful peptides andother fermentation products, and a process control system for large-scale biomanufacturing. The vectors will encode for the simultaneous expression and secretion of a target peptide and a reporter peptide that can be monitored on-line during fermentationto facilitate process control. The process control system will incorporate an enzyme assay and detector module to monitor the production of the target peptides and to control the fermentation process. The vectors and process control system will be usedto produce antibodies and peptides for a wide range of commercial and defense applications. During Phase II, we will complete construction of Gram negative, Gram positive, and broad-host-range expression vectors and couple them to suitable host organisms.We also will complete development of the fermentation control module, and perform pilot-scale fermentation experiments to calibrate the process monitoring system and to produce fermentation products in quantities sufficient to evaluation their commercialand defense utility."

* Information listed above is at the time of submission. *

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