Many commercial dyes have a benzidine base. evidence suggests a causal relationship between these dyes and bladder cancer in humans. routine short-term tests are inefficient for detection of the benzidine base dyes without modifications. short-term tests coupled to activation systems from rodent… More

Short-term/limited bioassays for the detection of chemical carcinogens, tumor initiators, and tumor promoters have been recognized as important components to the determinationof the carcinogenic hazard of environmental chemicals and complex mixtures. these bioassays are useful to determine (1)… More

The objective is the development of methods and reagents for use in the study of deletion mutations at the molecular level. such technology has not been developed for the analysis of deletion mutations which are induced by an important class of environmental mutagens/carcinogens and is necessary for… More

There is evidence that the excitotoxic action resulting from excessive accumulation of L-glutamate plays a prominent role in human epilepsy and brain ischemia/stroke, leading to neuronal dysfunction and cell death. The triazolines and the aminoalkylpyridine metabolite analogues are a group of novel… More