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BIOTINYLATED DNA PROBE FOR THE DIAGNOSIS OF CERVICAL CARCINO

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3045
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
3045
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Enzo Biochem Inc
325 Hudson St New York, NY 10013
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: BIOTINYLATED DNA PROBE FOR THE DIAGNOSIS OF CERVICAL CARCINO
Agency: HHS
Contract: N/A
Award Amount: $368,000.00
 

Abstract:

HUMAN PAPILLOMA VIRUS (HPV) INFECTIONS ARE A COMMON FORM OF SEXUALLY TRANSMITTED DISEASE. INFECTIONS WITH TWO STRAINS OF HPV, HPV-16 AND HPV-18, HAVE BEEN CORRELATED WITH CERVICAL CARCINOMA. DNA FROM THESE VIRUSES HAS BEEN DETECTED IN TUMOR TISSUE FROM PATIENTS WITH THIS MALIGNANCY. IN PHASE I OF THIS STUDY, WE WILL IDENTIFY AND ISOLATE REGIONS OF THE HPV-16 AND HPV-18 GENOMES THAT CAN SPECIFICALLY RECOGNIZE THESE VIRUSES IN CERVICAL CARCINOMA SAMPLES. THESE HPV-SPECIFIC DNA PROBES WILL PROVIDE THE BASIS FOR PHASE II STUDIES, WHERE WE WILL DEVELOP RAPID, SENSITIVE, SPECIFIC, AND SIMPLE NONRADIOACTIVE ASSAYS FOR THE DETECTION OF HPV-16 AND HPV-18 DNA DIRECTLY IN TISSUE SAMPLES TAKEN FROM PATIENTS WITH EITHER PAPILLARY WARTS OR CERVICAL CARCINOMA. THIS DNA-BASED DIAGNOSTIC SYSTEM WILL GREATLY FACILITATE THE EARLY DETECTION, DIAGNOSIS, AND TREATMENT OF PATIENTS WITH GENITAL HPV INFECTIONS. IT MAY ALSO PROVIDE THE BASIS FOR THE DEVELOPMENT OF A COMMERCIALLY RELEVANT ASSAY FOR DETECTING THE OCCURRENCE OR THE RECURRENCE OF CERVICAL CARCINOMA AT AN EARLY STAGE OF THE DISEASE.

Principal Investigator:

Hueylang Yang
Principal Investigator
2127413838

Business Contact:

Small Business Information at Submission:

Enzo Biochem Inc.
325 Hudson St. New York, NY 10013

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No