Adenosine deaminase (ada) and purine nucleoside phosphorylase (pnp) deficiencies are associated with certainimmunodeficiencies in humans. enzon will use patented methodology to prepare therapeutic modifications of ada and pnp. the procedure consists of attachment of monomethoxypolyethylene glycol… More

Cyanide is a rapidly acting poison that affects respiration in biological systems. victims may die in minutes. enzon, inc. is the exclusive licensee for a patented process for the chemical modification of enzymes that greatly extend their blood circulating life, eliminates or minimizes… More

The long-term goal of this project is to develop a thera- peutic uricase that can be used in hyperuricemia and the various manifestations of gout, including acute and chronic gouty arthritis tophi and urate deposits in tissues and organs, and uric acid nephropathy. it is expected that the… More

Cytomegalovirus (cmv), a member of the herpes virus group, is present in the blood of a large portion of the human population. administration of this blood to high-risk patients may result in death. enzo proposes the developmentof a quick, specific, easy and economical diagnostic test, based on… More

Enzon, inc. is involved in the development of therapeutic enzymes for human and veterinary use. many enzymes have shown effectiveness as anticancer agents on initial injection, but their immunogenicity and short plasma half-life have prevented exploitation of their potential. enzon, inc. will modify… More

Active oxygen species are implicated in many diseases. enzon is improving the therapeutic effectiveness of superoxide dismutase and catalase by our patented process so that these active oxygen-scavenging enzymes can be used routinely against active oxygen induced or exacerbated pathologies. the… More

The proposed effort is aimed at developing dual use concepts and techniques for use in rejuvenation of MMC components which contain classical creep-fatigue damage due to thermomechanical service loading and environment. Additionally, the research will include assessment of as manufactured MMC… More