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CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
1939
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
1939
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Ert
9653 Featherwood Lane Spring Valley, OH 45370
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL SYSTEMS.
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $78,625.00
 

Abstract:

CYANIDE IS A RAPIDLY ACTING POISON THAT AFFECTS RESPIRATION IN BIOLOGICAL SYSTEMS. VICTIMS MAY DIE IN MINUTES. ENZON, INC. IS THE EXCLUSIVE LICENSEE FOR A PATENTED PROCESS FOR THE CHEMICAL MODIFICATION OF ENZYMES THAT GREATLY EXTEND THEIR BLOOD CIRCULATING LIFE, ELIMINATES OR MINIMIZES IMMUNOGENICITY, AND INCREASES STABILITY. ENZYMES THUS MODIFIED ("PEG-ENZYMES") ARE EFFECTIVE THERAPEUTIC AGENTS. RHODANESE IS AN ENZYME THAT DETOXIFIES CYANIDE. ENZON WILL PREPARE PEG-RHODANESE AND EVALUATE IT FOR THERAPEUTIC EFFECTIVENESS AGAINST CYANIDE POISONING IN MICE. THE OBJECT IS TO DEVELOP A THERAPY THAT IS FAR SUPERIOR TO THOSE CURRENTLY AVAILABLE. IN ADDITION, THE PROPHYLACTIC EFFECTIVENESS OF PEG-RHODANESE WILL BE EVALUATED. THE GREATLY EXTENDED BLOOD LIFE OF PEG-RHODANESE SHOULD MAKE IT EFFECTIVE EVEN WHEN INJECTED SEVERAL HOURS PRIOR TO CYANIDE ADMINISTRATION. THE RESEARCH AND DEVELOPMENT WILL FEATURE (A) THE PURIFICATION OF RHODANESE; (B) ITS CHEMICAL MODIFICATION TO PRODUCE PEG-RHODANESE; (C) AN EVALUATION OF THE ACTIVITY, STABILITY, BLOOD CIRCULATING LIFE, AND IMMUNOGENICITY OF PEG-RHODANESE, AND (D) EVALUATION OF PEGRHODANESE'S THERAPEUTIC AND PROPHYLACTIC EFFECTIVENESS.

Principal Investigator:

Frank f davis
2016681800

Business Contact:

Small Business Information at Submission:

Enzon Inc
300c Corporate Ct South Plainfield, NJ 07080

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No