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THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4878
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4878
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Ert
9653 Featherwood Lane Spring Valley, OH 45370
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT CAN BE USED IN HYPERURICEMIA AND THE VARIOUS MANIFESTATIONS OF GOUT, INCLUDING ACUTE AND CHRONIC GOUTY ARTHRITIS TOPHI AND URATE DEPOSITS IN TISSUES AND ORGANS, AND URIC ACID
Agency: HHS
Contract: N/A
Award Amount: $43,000.00
 

Abstract:

THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A THERA- PEUTIC URICASE THAT CAN BE USED IN HYPERURICEMIA AND THE VARIOUS MANIFESTATIONS OF GOUT, INCLUDING ACUTE AND CHRONIC GOUTY ARTHRITIS TOPHI AND URATE DEPOSITS IN TISSUES AND ORGANS, AND URIC ACID NEPHROPATHY. IT IS EXPECTED THAT THE THERAPEUTIC URICASE WILL BE ABLE TO COMPLETELY REMOVE URATE DEPOSITS IN THE BODY. IT WILL ALSO CONTROL HYPERURICEMIA IFGIVEN AT INTERVALS IN SMALL AMOUNTS. THERAPEUTIC URICASE SHOULD BE ABLE TO DISSOLVE URATE DEPOSITS IN A MATTER OF HOURS OR DAYS, AND SHOULD PROVIDE IMMEDIATE RELIEF FOR ACUTEGOUTY ARTHRITIS ATTACKS, WITH NO LIKELIHOOD OF RECURRENCE. CANCER PATIENTS UNDERGOING AGGRESSIVE RADIATION OR CHEMO- THERAPY AGAINST LARGE TUMOR MASSES WILL BE PROTECTED FROM EXCESSIVE URATE PRODUCTION. THE SPECIFIC AIMS OF THIS PROJECT ARE TO MODIFY BY COVALENT ATTACHMENT OF MONOMETHOXY-POLYETHYLENE GLYCOL (PEG) A SELECTED URICASE WITH HIGH ACTIVITY, GOOD STABILITY, AND CONTROLLED IMMUNOGENICITY. PROCEDURES FOR DEVELOPING A HOMOGENEOUS PEG-URICASE ARE PROCEEDING. ANIMAL TOXICOLOGY STUDIES WILL BE DONE IN MICE,RATS, AND DOGS.

Principal Investigator:

Abraham abuchowski
PRINCIPAL INVESTIGATOR
2016681800

Business Contact:

Small Business Information at Submission:

Enzon Inc
Middlesex Business Center 300-c Corporate Court South Plainfield, NJ 07080

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No