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AMINO ACID-DEGRADING ENZYMES AS ANTICANCER AGENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7133
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7133
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Ert
9653 Featherwood Lane Spring Valley, OH 45370
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: AMINO ACID-DEGRADING ENZYMES AS ANTICANCER AGENTS
Agency: HHS
Contract: N/A
Award Amount: $47,000.00
 

Abstract:

ENZON, INC. IS INVOLVED IN THE DEVELOPMENT OF THERAPEUTIC ENZYMES FOR HUMAN AND VETERINARY USE. MANY ENZYMES HAVE SHOWN EFFECTIVENESS AS ANTICANCER AGENTS ON INITIAL INJECTION, BUT THEIR IMMUNOGENICITY AND SHORT PLASMA HALF-LIFE HAVE PREVENTED EXPLOITATION OF THEIR POTENTIAL. ENZON, INC. WILL MODIFY TWO GLUTAMINASE-ASPARAGINASES AND A HISTIDASE USING A PATENTED COMPANY PROCESS TO PRODUCE ENZYME-POLYETHYLENE GLYCOL (PEG) CONJUGATES WITH VASTLY IMPROVED PLASMA HALF-LIVES AND GREATLY REDUCED IMMUNOGENICITIES. THESE PEG ENZYMES CAN BE INJECTED REPEATEDLY SO THAT THEIR FULL THERAPEUTIC POTENTIAL CAN BE REALIZED. ENZON, INC. WILL PERFORM PLASMA HALF-LIFE AND INITIAL TOXICOLOGICAL STUDIES ON THE THREE PEG ENZYMES. THE LONG-TERM OBJECTIVE IS TO OBTAIN INVESTIGATIONAL NEW DRUG (IND) APPROVAL AND COMMENCE CLINICAL STUDIES. THESE ENZYMES ARE THE FORERUNNERS OF A LARGE GROUP OF NONESSENTIAL AND ESSENTIAL AMINO ACID-DEGRADING ENZYMES THATWILL BE DEVELOPED AS THERAPEUTIC AGENTS FOR VARIOUS TYPES OF CANCER.

Principal Investigator:

Frank f davis phd
2016681800

Business Contact:

Small Business Information at Submission:

Enzon Inc
300-c Corporate Court South Plainfield, NJ 07080

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No