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Company Information:

Company Name: ESA, INC.
City: CHELMSFORD
State: MA
Zip+4: 01824
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: (976) 250-7107

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $781,809.00 13
SBIR Phase II $2,783,290.00 5

Award List:

DESIGN OF N-ELECTRODE LCEC FOR BIOCHEMICAL ANALYSIS

Award Year / Program / Phase: 1984 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne R. Matson , Vice President
Award Amount: $50,000.00

A LONG-RANGE AIM OF THIS PROPOSED WORK IS TO DEVELOP A CLINICAL TEST BASED ON PATTERNS OF NEUROTRANSMITTERS (MONOAMINES, PEPTIDES/PRECURSORS, METABOLITES, AND CONJUGATES) WHICH CAN BE USED TO GUIDE AND DEVELOP THERAPY AND PREDICT OUTCOME IN PATIENTS WITH

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne r. matson , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
A long-range aim of this proposed work is to develop a clinical test based on patterns of neurotransmitters (monoamines, peptides/precursors, metabolites, and conjugates) which can be used to guide and develop therapy and predict outcome in patients with trigeminal neuralgia (tgm) and other forms of… More

DESIGN OF N-ELECTRODE LCEC FOR BIOCHEMICAL ANALYSIS

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency: HHS
Principal Investigator: Wayne R. Matson , Vice President
Award Amount: $500,000.00
Abstract:
A need exists for better devices and new instruments to enhance diagnostics and for application to physiology and pharmacology as outlined in the program specifications for nincds and nigms. the proposed work will study the engineering variables and applications of coulometric electrodes in series… More

METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne R Matson , Principal Investigator
Award Amount: $50,000.00

MULTIPARAMETER METABOLIC PATTERN INFECTION DIAGNOSIS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne r matson phd
Award Amount: $50,000.00
Abstract:
Continuous ambulatory peritoneal dialysis (capd) is now recognized as a feasible alternative for hemodialysis in end-stage renal failure. the rapid and potentially lethal development of peritonitis is a major limitation and concernfor the capd physician and patient. current conventional techniques… More

METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: Wayne R Matson , Principal Investigator
Award Amount: $500,000.00
Abstract:
Prototype multiple electrode liquid chromatography (n-elc) systems have been developed for simultaneous analysis of several hundred components in biological samples at the femtogram level. a major market for n-elc systems depends on the demonstration of the relevance of multicomponent measurements… More

INTEGRATED COLUMN/MULTISENSOR MICROBORE SYSTEM

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne R Matson
Award Amount: $50,000.00

INTEGRATED COLUMN/MULTISENSOR MICROBORE SYSTEM

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Wayne R Matson
Award Amount: $500,000.00
Abstract:
The basic characteristics of frit-type colorimetric sensors make them uniquely suited for high-sensitivity liquid chromatography electrochemical detection in microbore systems specifically engineered to optimize their properties. this research is based on optimizing a conceptually simple design in… More

Comparative Model for Immobility Osteopenia

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul E. Milbury
Award Amount: $50,000.00

PRODUCTION AND UTILIZATION OF 2.3-PENTANEDIONE FROM LACTIC ACID

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: USDA
Principal Investigator: Dr Prashant B Kokitkar
Award Amount: $50,000.00
Abstract:
Research is proposed to demonstrate the feasibility of 2,3-pentanedione production from lactic acid in a continuous, catalytic process. the increasing low-cost availability of lactic acid makes 2,3-pentanedione manufacture possible well below current costs and will open new markets for this… More

PROCESS FOR MAKING ETHYL DIHYDROXYBUTYRATE AND ETHYL GLYCOLATE FROM STARCH

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: USDA
Principal Investigator: Dr Carl W Niekamp
Award Amount: $50,000.00
Abstract:
The increase in the number of pure single enantiomer drug products entering the market has been spurred on by the recent change in the fda's drug guidelines. this change has created a large demand for optically-pure, chiral synthons or building block intermediates by the pharmaceutical companies.… More

Comparative Model for Immobility Osteopenia

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Paul E. Milbury
Award Amount: $534,549.00
Abstract:
The mechanism of immobility osteopenia is a complex phenomenon of both biochemical and mechanical etiology. This study is designed to investigate the hypothesis that changes in patterns of both known and unknown small molecular weight compounds (e. g., tyrosine and tryptophan metabolites,… More

Technology for Clinical Management of Oxidative Stress

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne Matson
Award Amount: $99,999.00

Evidence of Reductive Dechlorination and Mineralization of Lower Chlorinated Biphenyls by Anaerobic Microbi

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: NSF
Principal Investigator: Murugiah Natarajan
Award Amount: $64,913.00

Production of Phytase for Use in Animal Feed

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: USDA
Principal Investigator: Dr. Thomas L. Deits , Principal Investigator
Award Amount: $50,000.00
Abstract:
There is a substantial and growing interest among swine and poultry producers in the application of phytase to improve the nutritional quality in animal feeds. Demonstrated benefits include improved feed yield ratios and reduction in the environmental costs associated with the disposal of animal… More

Technology for Clinical Management of Oxidative Stress

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Wayne Matson
Award Amount: $748,741.00
Abstract:
We will develop technology for assessing and managing oxidative stress in neurodegenerative disordePhase I aims are defining urine plasma levels of twelve proposed purine, hydroxyl, and nitrohydroxyspectrum of neurodegenerative diseases; evaluating challenge tests for over production and under… More

SBIR Phase I: A New Approach to Low Cost Enzyme Expression in Bacillus

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: NSF
Principal Investigator: Thomas Deits
Award Amount: $74,995.00

TECHNOLOGY FOR DNA DAMAGE MARKERS IN CERVICAL CANCER

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Wayne R. Matson
Award Amount: $91,902.00
Abstract:
Prototype carbon column switching (CCS) systems (1) have been applied to measuring free levels of DNA adducts in PAP smear and cervico vaginal lavage sample indicating a possible correlation with various risk factors and cancer. Preliminary work has defined some of the possible role of utility of… More