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METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
5303
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
5303
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ESA, INC.
22 ALPHA RD CHELMSFORD, MA 01824
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1989
Title: METHODS FOR KYNURENINE SYSTEM IN HUNTINGTON'S DISEASE
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

PROTOTYPE MULTIPLE ELECTRODE LIQUID CHROMATOGRAPHY (N-ELC) SYSTEMS HAVE BEEN DEVELOPED FOR SIMULTANEOUS ANALYSIS OF SEVERAL HUNDRED COMPONENTS IN BIOLOGICAL SAMPLES AT THE FEMTOGRAM LEVEL. A MAJOR MARKET FOR N-ELC SYSTEMS DEPENDS ON THE DEMONSTRATION OF THE RELEVANCE OF MULTICOMPONENT MEASUREMENTS TO DEGENERATIVE NEUROLOGICAL DISORDERS. RECENTLY, QUINOLINIC ACID (QA) HAS BEEN SHOWN TO REPLICATE THE HISTOLOGICAL AND NEUROCHEMICAL FEATURES OF HUNTINGTON'S DISEASE (HD), A PROGRESSIVE DEGENERATIVE NEUROLOGICAL DIS- ORDER. ESA WILL DEVELOP AND APPLY N-ELC METHODS FOR THE ANALYSIS OF THE KYNURENINE (KY) PATHWAY LEADING TO THE QA. THE INTENT IS TO DEVELOP PROCEDURES CAPABLE OF LOCATING A METABOLIC DEFECT IN HD LEADING TO INCREASED QA ACCUMULATION.SIMULTANEOUSLY, THE N-ELC PROCEDURES WILL PROVIDE INFORMA- TION ON THE APPROXIMATELY 40 OTHER COMPONENTS OF THE TYROSINE AND TRYPTOPHAN PATHWAYS. THESE DATA WILL BE USED TO QUALIFY THE KY PATHWAY AND IMPROVE INTERCLASS CORRELA- TIONS BETWEEN HD AND NORMALS. AS PART OF AN ONGOING PROGRAMAT MGH, THE SAMPLES WILL ALSO BE ASSAYED FOR QA, AMINO ACIDS, AND NEUROPEPTIDES. THE LONG-RANGE AIM OF THE PROJECTIS TO DEFINE THE NEUROCHEMICAL PATHWAYS IN HD IN SUFFICIENT DETAIL TO GUIDE PHARMACOLOGICAL INTERVENTION.

Principal Investigator:

Wayne R Matson
Principal Investigator
6172750100

Business Contact:

Small Business Information at Submission:

Esa Inc.
45 Wiggins Avenue Bedford, MA 01730

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No