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MULTIPARAMETER METABOLIC PATTERN INFECTION DIAGNOSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7222
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7222
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ESA, INC.
22 ALPHA RD CHELMSFORD, MA 01824
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: MULTIPARAMETER METABOLIC PATTERN INFECTION DIAGNOSIS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD) IS NOW RECOGNIZED AS A FEASIBLE ALTERNATIVE FOR HEMODIALYSIS IN END-STAGE RENAL FAILURE. THE RAPID AND POTENTIALLY LETHAL DEVELOPMENT OF PERITONITIS IS A MAJOR LIMITATION AND CONCERNFOR THE CAPD PHYSICIAN AND PATIENT. CURRENT CONVENTIONAL TECHNIQUES FOR CULTURING, DETECTING, AND CLASSIFYING INFECTION IN CAPD ARE NOT FULLY ADEQUATE TO TREAT PERITONITIS. THE RECENT DEVELOPMENT OF COMPUTERIZED, MULTIPLE ELECTROCHEMICAL SENSOR CHROMATOGRAPHY TECHNOLOGY (N-ELC) OFFERS A ROUTE TO A RAPID INSTRUMENTAL DIAGNOSIS OF CAPD INFECTION THROUGH THE DETECTION OF UNIQUE, SMALL-MOLECULE PATHOGEN METABOLITES. CURRENT N-ELC TECHNOLOGY TAKES 60 MINUTES TO SEPARATE AND CAN DETECT APPROXIMATELY 250 COMPOUNDS IN PERITONEAL DIALYSATE AT FEMTOGRAM SENSITIVITIES. PRELIMINARY WORK HAS INDICATED THAT 6 TO 8 OF THESE ARE ASSOCIATED WITH INFECTION. THE PROPOSED WORK INVOLVES VERIFICATION AND IDENTIFICATION OF UNIQUE MARKERS AND THE DEVELOPMENT OF RAPID N-ELC TESTINGPROTOCOLS TO OPEN A MARKET FOR THE CURRENT N-ELC RESEARCH EQUIPMENT IN INFECTIOUS DISEASES.

Principal Investigator:

Wayne r matson phd
6172750100

Business Contact:

Small Business Information at Submission:

Esa Inc
45 Wiggins Avenue Bedford, MA 01730

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No