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Diagnostic Reagents for Emerging Infectious Diseases

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54239
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43AI050262-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EPIVAX, INC.
146 CLIFFORD STREET PROVIDENCE, RI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Diagnostic Reagents for Emerging Infectious Diseases
Agency: HHS
Contract: N/A
Award Amount: $105,609.00
 

Abstract:

DESCRIPTION (provided by applicant): West Nile virus (WNV) is a flavivirus commonly found in Africa, West Asia, and the Middle East. The virus was introduced into the United States in 1999. Case-fatality rates during the 1999-2000 U.S. epidemics ranged from 3 percent to 15 percent and were highest in the elderly. The virus is expected to over-winter during 2000-2001 and re-emerge in the Northeast over a wider area. The goal of this project is to develop epitope reagents that could be used in a diagnostic test (such as a tetramer assay) for cell-mediated response to WNV. These reagents may be useful for screening exposed individuals, for investigating the immunopathogenesis of WNV disease in humans, as a component of the surveillance effort and/or, eventually, as a tool for measuring WNV vaccine-related immune responses. The specific aims of this project are to: Select WNV "unique" sequences for potential immunogenicity, using EpiVax tools Confirm MHC binding of selected ligands in T2 MHC binding assays Confirm T cell response to the WNV epitopes by ELIspot assay Begin the process of constructing several tetramers containing WNV epitopes with the NIH tetramer contract service. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Principal Investigator:

Anne S. Degroot

Business Contact:


4012722123
ANNIED@EPIVAX.COM
Small Business Information at Submission:

EPIVAX, INC.
365 HOPE ST PROVIDENCE, RI 02906

EIN/Tax ID: 050499380
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No