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THIS GRANT IS TO DEVELOP A THROMBORESISTANT, HEPARINIZED BLOOD COMPATIBLE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
476
Program Year/Program:
1983 / SBIR
Agency Tracking Number:
476
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EQUAL ACCESS TO SCIENTIFIC EXCELLENCE
EQUAL ACCESS TO SCIENTIFIC EXCELLENCE SOUTH SAN FRANCISCO, CA 94080
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1983
Title: THIS GRANT IS TO DEVELOP A THROMBORESISTANT, HEPARINIZED BLOOD COMPATIBLE MATERIAL.
Agency: HHS
Contract: N/A
Award Amount: $48,000.00
 

Abstract:

THIS GRANT IS TO DEVELOP A THROMBORESISTANT, HEPARINIZED BLOOD COMPATIBLE MATERIAL. THE GRANTEE WILL TEST BLOOD MATERIAL SURFACE INTERACTIONS AND COMPATIBILITY. IN IMPROVING THE THROMBORESISTANCE OF HEPARINIZED SURFACES, THE COVALENT-BONDED HEPARIN SHOULD POSSESS ENOUGH MOBILITY THAT GIVES ITSELF THE SAME MOLECULAR SHAPE AND SIZE AS IT DOES IN A FREELY-SOLUBLE STATE. TO TEST THIS HYPOTHESIS, A CONVENTIONAL COVALENTLY-BONDED HEPARINIZED STYRENE-BUTADIENESTYRENE BLOCK COPOLYMER WILL BE SYNTHESIZED AS THE CONTROL. THE PROPOSED MATERIAL HAS THE SAME STRUCTURE AS THE CONTROL EXCEPT HYDROPHILLIC POLYMER CHAIN IS INSERTED BETWEEN THE POLYMER SURFACE AND THE PENDENT HEPARIN TO GIVE THE DESIRED MOBILITY. THE LENGHT OF THE POLYMER CHAIN CAN BE PRECISELY CONTROLLED BY LIVING POLYMERIZATION. POLY(OXYETHYLENE) HAS BEEN CHOSEN AS THE HYDROPHILLIC CHAIN. IT GIVES PENDENT HEPARIN MOBILITY AND ALSO ACTS AS A HYDROGEL REDUCING THE ABSORPTION OF BLOOD COMPONENTS.

Principal Investigator:

Daniel m. chang
PRINCIPAL INVESTIGATOR
9164433932

Business Contact:

Small Business Information at Submission:

Eureka Laboratories Inc
215-26th Street Sacramento, CA 95816

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No