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Software Guided Localization of the Subthalamic Nucleus During DBS Surgeries

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
96446
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
NS064640
Solicitation Year:
N/A
Solicitation Topic Code:
NINDS
Solicitation Number:
N/A
Small Business Information
FHC, INC.
1201 MAIN ST BOWDOIN, ME 04287-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Software Guided Localization of the Subthalamic Nucleus During DBS Surgeries
Agency: HHS
Contract: 1R43NS064640-01A2
Award Amount: $202,186.00
 

Abstract:

DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective treatment of Parkinson disease. Because the STN is small (9 X 7 X 4 mm) and it is not well visible using conventional imaging techniques, microe lectrode recordings (MER) is used to ensure accurate detection of the STN borders. Commonly used MER techniques are subjective, time consuming and require an experienced electrophysiologist. Therefore, there is an urgent need to develop new methodologies f or accurate and objective detection of the subthalamic nucleus during microelectrographic recordings. In this proposal we will utilize the multi-unit spiking activity (MSA) for detection of the STN borders. The MSA is characteristically elevated within the STN that facilitates unambiguous delineation of both the dorsal and ventral STN borders. The proposed approach enables exact and uniform placement of the stimulation electrodes that can improve outcome of the DBS surgeries. The proposed method is straight forward and has the potential to be used widely in clinical practice. The proposed project will involve work to translate the standalone, off-line MSA analysis into a real time analytical tool that is integrated into a currently available clinical electrop hysiological workstation (FHC's Guideline 4000) for use in current functional neurosurgical procedures. PUBLIC HEALTH RELEVANCE: Project Narrative Deep brain stimulation of the subthalamic nucleus using electric current is an effective treatment of Parkins on disease (1-2). The accurate and reliable methods for detection of the target of stimulation are lacking. In this project, we implement a method for target detection based on an activity of the cells in the target (22) that enables accurate placement of the stimulating electrode. This approach can be widely used in clinical practice and it can improve outcomes of deep brain stimulation surgeries.

Principal Investigator:

Lee D. Margolin
2076668190
LMARGOLIN@FH-CO.COM

Business Contact:

David L. Margolin
lmargolin@fh-co.com
Small Business Information at Submission:

FHC, INC.
FHC, INC. 1201 MAIN ST BOWDOIN, ME 04287

EIN/Tax ID: 101043088
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No