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Company Information:

Company Name: EXEMPLAR GENETICS, LLC
City: SIOUX CENTER
State: IA
Zip+4: -
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $938,814.00 6
SBIR Phase II $3,081,311.00 3

Award List:

Development of a Humanized Pig Model of Cystic Fibrosis

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,537.00
Abstract:
DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most CF patients have a mutation that deletes… More

Development of a Humanized Pig Model of Cystic Fibrosis

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: HHS
Principal Investigator: Christopher Rogers
Award Amount: $623,617.00
Abstract:
DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most CF patients have a mutation that deletes… More

Development of a Porcine Model of Atherosclerosis

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Christopher Rogers
Award Amount: $129,935.00
Abstract:
DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposi ts, and cellular debris in vessel walls,… More

Development of a Porcine Model of Duchenne Muscular Dystrophy

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Christopher Rogers – 319-665-2664
Award Amount: $160,566.00
Abstract:
DESCRIPTION (provided by applicant): Project Summary/Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutations in the DMD gene with a prevalence of 1 in 3500 male births. The consequent loss of functional dystrophin results in the progressive degeneration… More

Development of a Porcine Model of Ataxia-Telangiectasia

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Christopher Rogers – 319-665-2664
Award Amount: $156,826.00
Abstract:
DESCRIPTION (provided by applicant): Ataxia-Telangiectasia (A-T) is a multi-systemic, recessively inherited disorder characterized primarily by early onset cerebellar ataxia and telangiectasia, from which the disease name is derived. In addition, patientsalso exhibit a number of other clinical… More

Development of a Porcine Model of Atherosclerosis

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Christopher Rogers – 319-665-2664
Award Amount: $1,246,253.00
Abstract:
DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and… More

Development of a Porcine Model of Ataxia-Telangiectasia

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Christopher Rogers – 319-665-2664
Award Amount: $1,211,441.00
Abstract:
DESCRIPTION (provided by applicant): Ataxia-telangiectasia (A-T) is a multi-systemic, recessively inherited disorder that affects between 1 in 40,000 to 1 in 100,000 individuals worldwide. It is characterized primarily by early onset cerebellar ataxia andtelangiectasia, from which the disease name… More

P53 and KRAS Targeted Pigs: A Platform for Models of Human Cancer

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Christopher Rogers – 319-665-2664
Award Amount: $167,065.00
Abstract:
Project Summary/Abstract Cancer is the second deadliest disease in the United States, killing more than 500,000 Americans annually. This year, another 1.5 million will be diagnosed with one of nearly 200 different cancer types. Despite an ever---growing understanding of the environmental risk… More

Development of a Porcine Model of Juvenile Neuronal Ceroid Lipofuscinosis

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Christopher Rogers – 319-665-2664
Award Amount: $224,885.00
Abstract:
DESCRIPTION (provided by applicant): Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is an autosomal recessive disorder caused by mutations in the CLN3 gene with a worldwide incidence of 1 in 12,500 live births. It is part ofa group of lysosomal storage disorders - the… More