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Fullerene Nanomedicine to Enhance Neuronal Adenosine Triphosphate Production…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
92165
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
A092-059-0905
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Luna Innovations Incorporated
1 Riverside Circle Suite 400 Roanoke, VA 24016-4962
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Fullerene Nanomedicine to Enhance Neuronal Adenosine Triphosphate Production Capacity
Agency / Branch: DOD / ARMY
Contract: W911NF-10-C-0010
Award Amount: $69,996.00
 

Abstract:

Cognitive performances are significantly reduced for older soldiers, due to the reduced production of the primary energy molecule of the body - adenosine triphosphate. The aging-dependent mitochondrial insufficiency is thought to play a dominating role. The development of a therapeutic drug which can enhance ATP production and improve energetic capability is crucial to maintain soldiers' performance and extend their duty-time. The current attempts to counter mitochondrial insufficiency include frequent exercise and antioxidants, but the effects are very limited. Luna Innovations proposes to use nanomedicine technology to develop prototype compounds with stimulatory effects on neuronal ATP production. Luna has developed an extensive portfolio of fullerene nanosphere compounds which showed promises in treating aging-related diseases. Fullerene nanospheres are thought to scavenge the toxic free radicals generated in mitochondria, enhance the electron transport capacity in oxidative phosphorylation, and build a greater potential gradient across the inner membrane, efficiently driving ATP Synthase. In Phase I, Luna will develop and validate a high throughput screening assay based on the ATP-requiring luciferin-luciferase bioluminescence, and test nanosphere compounds to build a structure-activity relationship for designing and testing more compounds in Phase II.

Principal Investigator:

Zhiguo Zhou
Principal Investigator
4344834234
submissions@lunainnovations.com

Business Contact:

Maggie Hudson
Contracts Administrator
4344834254
submissions307@lunainnovations.com
Small Business Information at Submission:

LUNA INNOVATIONS, INC.
1 Riverside Circle Suite 400 Roanoke, VA 24016

EIN/Tax ID: 541560050
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No