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ULTRA SENSITIVE SECONDARY ION MASS SPECTROMETRY OF ORGANICS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8039
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8039
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Fei Co
19500 Nw Gibbs Dr - Ste 100 Beaverton, OR 97006
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: ULTRA SENSITIVE SECONDARY ION MASS SPECTROMETRY OF ORGANICS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE SPECTROMETRIC ANALYSIS OF LARGE, LABILE, POLAR MOLECULESIS OF GREAT IMPORTANCE TO RESEARCH IN A BROAD SPECTRUM OF SCIENTIFIC DISCIPLINES. THIS PROJECT IS CONCERNED WITH THE RELATIVELY LOW SENSITIVITY OF SECONDARY IONIZATION MASS SPECTROMETRY PERFORMED ON LIQUID SAMPLE MATRICES, A FORM OF MASS SPECTROMETRY CAPABLE OF ANALYZING LARGE, ORGANIC MOLECULES. AN OPPORTUNITY EXISTS FOR INCREASING THE SENSITIVITY OF THIS IMPORTANT TECHNIQUE BY AS MUCH AS TWO OR THREE ORDERS OF MAGNITUDE. MORE SPECIFICALLY, THROUGH A COMBINATION OF SYSTEMATIC INVESTIGATION AND INNOVATIVE USE OF A LIQUID METAL ION SOURCE IN CONJUNCTION WITH A FINE FOCUSED ION COLUMN, IT SHOULD BE POSSIBLE TO GREATLY REDUCE THE ABSOLUTE AMOUNT OF ANALYTE REQUIRED FOR ANALYSIS, TO INCREASE THE EFFICIENCY OFANALYZING THE ANALYTE MOLECULES, AND TO SUBSTANTIALLY INCREASE THE EFFICIENCY OF COLLECTING THE ANALYTE IONS FOR TRANSMISSION THROUGH THE MASS ANALYZER. A SUCCESSFUL OUTCOME OF THIS PROJECT WOULD HAVE A SIGNIFICANT TECHNOLOGICAL IMPACT ON BIOMEDICAL RESEARCH AND WOULD STIMULATE FURTHER ADVANCES IN HIGH-SENSITIVITY ANALYSES BY MASS SPECTROMETRY. MOREOVER, THE DEVELOPMENT OFA LIQUID METAL ION-FOCUSING COLUMN FOR ULTRASENSITIVE, LIQUID-MATRIX, SECONDARY IONIZATION MASS SPECTROMETRY COULD HELP THE NATION REGAIN SOME OF ITS TECHNICAL AND ECONOMIC COMPETIVENESS IN THE IMPORTANT FIELD OF MASS SPECTROMETRY.

Principal Investigator:

Lynwood swanson
5036901500

Business Contact:

Small Business Information at Submission:

Fei Co
2575 Northeast Kathryn St #34 Hillsboro, OR 97124

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No