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PANEL OF MONOCLONAL ANTIBODIES TO COMMON IDIOTOPES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11075
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11075
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Ferlyn Biomedical
2022 Brookwood Medical Ctr Dr Ste 515 Birmingham, AL 35209
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: PANEL OF MONOCLONAL ANTIBODIES TO COMMON IDIOTOPES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

ANTI-IDIOTYPE (ANTI-ID) ANTIBODIES RECOGNIZE DETERMINANTS OF THE IMMUNOGLOBULIN VARIABLE REGION THAT ARE INDIVIDUALLY SPECIFIC TO THE IMMUNIZING ANTIBODY. FRUITFUL IN MANY SCIENTIFIC FIELDS AND PROMISING IN CLINICAL TRIALS OF COMBINATION IMMUNOTHERAPY, THEY ARE UNFORTUNATELY ONE OF THE MOST LABORIOUS BIOLOGICAL REAGENTS TO CONSTRUCT. IN THE COURSE OF TRACING THE ORIGINS OF B-CELL MALIGNANCIES,IT WAS FOUND THAT MONOCLONAL ANTI-ID ANTIBODIES REACT WITH VARYING PROPORTIONS (<0.1 TO 10 PERCENT) OF NORMAL HUMAN B-LINEAGE CELLS. IN THE PRESENT STUDY, FERLYN BIOMEDICAL WILL RAISE ANTI-ID ANTIBODIES AND SELECT FOR ANTIBODIES CROSS-REACTIVE TO A HIGH PROPORTION OF HUMAN PLASMA CELLS AND MONOCLONAL IMMUNOGLOBULINS. SELECTED ANTIBODIES WILL BE TESTED FOR PREFERENTIAL REACTIVITY TO ID(+) ANTIBODIES OF A PARTICULAR ISOTYPE AND FOR FINE SPECIFICITY BY INHIBITION ASSAYS. THE PANEL OF EXISTING AND NEW ANTI-ID ANTIBODIES WILL BE USED TO SCREEN FOR EXPRESSION OF CROSS-REACTIVE ID'S BY B-CELL MALIGNANCIES AND HUMAN IMMUNOGLOBULINS OF CLINICAL AND RESEARCH INTEREST. THIS APPROACH COULD SPARE PATIENTS AND RESEARCHERS THE LONG DELAY IN PRODUCING TAILORMADE ANTI-ID ANTIBODIES, PROVIDING THEM WITH REAGENTS FOR IMMEDIATE USE TO MONITOR OR TREAT B-CELL DISORDERS. A PANEL OF CROSS-REACTIVE ANTIBODIES WOULD LOWER THE COSTS OF ANTI-ID PRODUCTION AND ENHANCE THEIR ROLE IN CLINICAL RESEARCH.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Ferlyn Biomedical
2022 Brookwood Medical Ctr Dr Ste 515 Birmingham, AL 35209

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No