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High-Resolution Ion Beam Probe for Biological Research

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60640
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
EB000387
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Fm Technologies, Inc.
4431-H Brookfield Corporate Dr Chantilly, VA 20151-1691
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2004
Title: High-Resolution Ion Beam Probe for Biological Research
Agency: HHS
Contract: 9R44CA111311-02
Award Amount: $825,491.00
 

Abstract:

DESCRIPTION (provided by applicant): Mapping the distribution of targeted chemical species in tissues is very important in many areas of biology and medicine. A useful methodology for these measurements would be one that is sensitive enough to give an accurate measure of the minute quantities of material in cells as well as possess the spatial resolution to distinguish organelles. Towards this end, Secondary Ion Mass Spectroscopy (SIMS) has inherent analytical properties to meet the need. A critical goal for an advanced SIMS instrument for ultra-fine imaging at the cellular and sub-cellular level is the development of a high-brightness ion beam probe, especially with negative oxygen ion beams, to yield ~10-20 nm resolution for a beam current of ~1 pA. The best results today fall short of these specifications by more than an order of magnitude. The experiments and design calculations in Phase I demonstrate feasibility of the overall technical objectives, and provide strong guidance for developing a credible Phase II plan during which a negative oxygen ion primary beam probe will be built, optimized and tested. The new ion beam probe being developed at FMT under this NIH-sponsored SBIR program will improve the current state-of-the art for O- beams by 1 to 1.5 orders of magnitude and allow making a quantum leap in the race for high-resolution in SIMS. Our goal is to apply the final product for spectroscopic imaging of the distribution of chemical components of cells with about 10-20-nanometer resolution. This will help cross the present technological barrier for addressing several fundamental problems in cell biology relevant to studies of carcinogenesis, toxicology, neurochemistry as well as the treatment of several diseases including cancer. While this work focuses on mapping fine-scale distribution of targeted chemical species in cancer cells, success of this project will immediately benefit a broad range of disciplines in science and technology including many other areas in biology, medicine and nanotechnology.

Principal Investigator:

Samar K. Guharay
7038189400
sguharay@fm-technologies.com

Business Contact:

Frederick Mako
7038189400
FMAKO@EROLS.COM
Small Business Information at Submission:

FM TECHNOLOGIES, INC.
4431-H BROOKFIELD CORPORATE DRIVE CHANTILLY, MD 20151

EIN/Tax ID: 541423431
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No