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Platelet-based Nanoparticle Therapy for Prostate Cancer

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94155
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
N43CO0800063
Solicitation Year:
N/A
Solicitation Topic Code:
NCI
Solicitation Number:
N/A
Small Business Information
ANDROBIOSYS, INC.
875 Ellicott St BUFFALO, NY 14203-1070
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: Platelet-based Nanoparticle Therapy for Prostate Cancer
Agency: HHS
Contract: N44CO201000119
Award Amount: $999,642.00
 

Abstract:

The goal of this Phase II proposal is to develop directed energy transfer methods for imaging, tissue ablation and release of therapeutic modalities targeted to the vasculature of prostate cancer. The platform technology is a freeze-dried human platelet (Stasix particles) that contains super paramagnetic iron oxide (SPIO) nanoparticles. The Phase I program showed that SPIO-Stasix particles selectively localize to damaged vasculature in human prostate xenografts on immunocompromised mouse hosts. We propose to further validate the use of human platelet products loaded with iron oxides as delivery vehicles for imaging and therapeutic modalities; to use phage display technology to enhance the targeting of human platelet nanoparticles or synthetic microdevices to prostate cancer microvasculature; to demonstrate that nanodevices targeted to prostate microvasculature can initiate targeted heat-induced damage of the prostate; and to validate and test in clinical trials the therapeutic window induced by androgen deprivation therapy in prostate cancer patients. This proposal represents a full characterization of the targeting, imaging and delivery of heat therapy and contrast agents to prostate microvasculature as a tool for the treatment and diagnosis of prostate cancer.

Principal Investigator:

Michael Zwick
Small Business Information at Submission:

ANDROBIOSYS, INC.
Elm and Carlton Streets BUFFALO, NY 14263-

EIN/Tax ID: 202315778
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No