USA flag logo/image

An Official Website of the United States Government

GAMMA ASSOCIATES PROPOSES TO PRODUCE FOR COMMERCIAL PURPOSESHUMAN MONOCLONAL…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4980
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4980
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Gamma Associates
61 West 62nd Street New York, NY 10023
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: GAMMA ASSOCIATES PROPOSES TO PRODUCE FOR COMMERCIAL PURPOSESHUMAN MONOCLONAL ANTIBODIES AGAINST RH ANTIGENS ON HUMAN BLOOD CELLS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

GAMMA ASSOCIATES PROPOSES TO PRODUCE FOR COMMERCIAL PURPOSESHUMAN MONOCLONAL ANTIBODIES AGAINST RH ANTIGENS ON HUMAN BLOOD CELLS. THE PROJECT HAS BECOME FEASIBLE THROUGH NEWLY DEVELOPED METHODOLOGY ACCESSIBLE TO THE COMPANY. PRODUCTIONSTRATEGY WILL ENTAIL THE TRANSFORMATION BY EPSTEIN-BARR VIRUS OF IMMUNE B CELLS OBTAINED FROM DONORS WHO HAVE HIGH ANTI-RH TITERS AS A RESULT OF RH-INCOMPATIBLE PREGNANCY. LYMPHOBLASTOID CELL LINES THAT PRODUCE RH-SPECIFIC ANTI- BODIES WILL BE STABILIZED BY REPEATED CLONING. CLONED CELLSWILL BE FUSED TO THE HETEROMYELOMA CELL LINE DE33 OR EQUIVALENT MYELOMA CELLS TO PROVIDE HIGH-SECRETING HYBRID- OMAS. THE SPECIFICITY OF ANTI-RH ANTIBODY WILL BE EVALUATEDBY TESTING ON A PANEL OF KNOWN HUMAN RED BLOOD CELLS AND BY SEGREGATION ANALYSIS. THE PURPOSE OF THIS RESEARCH IS TO COLLECT A LARGE SET OF STANDARDIZED, REPRODUCIBLE MONOCLONALANTIBODIES FOR DIAGNOSTIC TYPING OF THE HUMAN RH ANTIGEN SYSTEM. THE COMPANY ANTICIPATES THAT RELEVANT ANTIBODIES WILL EVENTUALLY BE USED FOR PROPHYLACTIC DESENSITIZATION OF WOMEN WHO BEAR RH-INCOMPATIBLE FETUSES. HYBRIDOMA-DERIVED RH ANTIBODIES WILL CONSTITUTE AN INVALUABLE RESOURCE TO REPLACE THE DWINDLING SUPPLY OF NATURALLY OCCURRING RH- IMMUNE GAMMA GLOBULIN.

Principal Investigator:

Kittie a murray
PRINCIPAL INVESTIGATOR
2125822585

Business Contact:

Small Business Information at Submission:

Gamma Associates
61 West 62nd Street New York, NY 10023

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No