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RAPID TEST TO MONITOR BLOOD MANNOSE LEVELS

Award Information

Agency:
Department of Defense
Branch:
Navy
Award ID:
8666
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8666
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Gds Technology, Inc.
25235 LEER DR Elkhart, IN 46514
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: RAPID TEST TO MONITOR BLOOD MANNOSE LEVELS
Agency / Branch: DOD / NAVY
Contract: N/A
Award Amount: $49,960.00
 

Abstract:

D-MANNOSE CONCENTRATIONS IN BLOOD APPARENTLY INCREASE IN PATHOLOGICAL SITUATIONS SUCH AS SEPTIC SHOCK OR INFECTIONS BY FUNGUS OR GRAM NEGATIVE ORGANISMS. THEREFORE, AN ACCURATE AND SIMPLE METHOD FOR THE MEASUREMENT OF MANNOSE IS VITAL FOR DETERMINATION OF THE STATUS OF THE DISEASE. DMANNOSE IS GENERALLY MEASURED BY GAS LIQUID CHROMATOGRAPHY OR BY A SEVERAL STEP ENZYMATIC APPROACH WHICH IS INCONVENIENT AND TIME CONSUMING. ALTERNATIVELY, A RAPID TEST TO MONITOR BLOOD MANNOSE USING AN ENZYME WHICH WILL DIRECTLY OXIDIZE D-MANNOSE SPECIFICALLY IS PROPOSED HERE. AS SUCH AN ENZYME IS NOT COMMERCIALLY AVAILABLE OR KNOWN, THE RESEARCH PROPOSAL FOCUSES ON SCREENING AND FINDING A SUITABLE ORGANISM WHICH IS CAPABLE OF PRODUCING D-MANNOSE OXIDASE/DEHYDROGENASE (PHASE I). THE GOAL OF PHASE II WILL BE TO ISOLATE AND PURIFY THE MANNOSE OXIDIZING ENZYME AND USING THIS ENZYME TO DEVELOP A LIQUID TEST OR A DRY CHEMISTRY TEST STRIP FOR D-MANNOSE (SIMILAR TO AMES' OR BOEHRINGER'S WHOLE BLOOD GLUCOSE STRIP TEST). THE TEST WILL BE SIMPLE TO PERFORM AND WILL YIELD FAST AND ACCURATE RESULTS.

Principal Investigator:

Dr aurora f decastro
2192647384

Business Contact:

Small Business Information at Submission:

Gds Technology Inc
Po Box 473 - 25235 Leer Dr Elkhart, IN 46515

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No