The problem to be addressed involves a well documented concern in the field of intravenous therapy and invasive hemodynamic monitoring. fluid filled catheters, while infusing fluids into the blood vessels, can carry bacteria into a patient's blood, leading to nosocomial bacteremias. the part of the… More

DESCRIPTION (provided by applicant): To develop an effective drug for oral mucositis Background: Oral mucositis is a painful dose-limiting side effect of many forms of cancer radiation and chemotherapy. According to a recent report by the National Comprehe nsive Cancer Network, mucositis is the most… More

DESCRIPTION (provided by applicant): Project Summary Long Term Goal: To develop a drug for treating inflammatory bowel disease with reduced side effects Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. There are two types of inflammatory… More

DESCRIPTION (provided by applicant): Celiac disease is a common and debilitating gastrointestinal disorder. It is caused by an inappropriate immunological response to gluten. Although celiac disease can usually be controlled by strict avoidance of gluten in the diet, the ubiquity of gluten in the… More

DESCRIPTION (provided by applicant): To develop an oral anti-TNF antibody therapeutic that is safe and effective enough to be used as a first line therapy for inflammatory bowel disease. Problem: Inflammatory bowel disease (IBD) comprises two chronic inflammatory disorders of the gastrointestinal… More