USA flag logo/image

An Official Website of the United States Government

HUMAN MONOCLONAL ANTIBODIES TO HLA-DR DETERMINANTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2933
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
2933
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NEUGENESIS CORPORATION
NEUGENESIS CORPORATION 871 INDUSTRIAL RD, STE J SAN CARLOS, CA 94070
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: HUMAN MONOCLONAL ANTIBODIES TO HLA-DR DETERMINANTS
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE IMMUNE RESPONSE IN MAN IS REGULATED BY ORDERED INTERACTIONS BETWEEN FUNCTIONALLY AND PHENOTYPICALLY DISTINCT LYMPHOID CELLS (T CELLS AND THEIR SUBSETS, B CELLS AND MONOCYTES) IN THE CONTEXT OF IA-LIKE MOLECULES ENCODED BY THE HLA COMPLEX OF GENES. THUS, THE PRODUCTS OF THESE GENES (E.G., DR, DS, SB) CONTROL THE PROLIFERATIVE RESPONSE OF T CELLS IN MIXED LYMPHOCYTE REACTIONS, ANTIGEN PRESENTATION TO T CELLS BY MACROPHAGES AND COLLABORATION BETWEEN T AND B CELLS. TEN ALLELES OF THE HLA-DR LOCUS HAVE BEEN IDENTIFIED AND, IN ADDITION TO INFLUENCING ALLOGRAFT SURVIVAL, ALLELES OF THIS LOCUS HAVE BEEN ASSOCIATED WITH SUSCEPTIBILITY TO A NUMBER OF DISEASES INCLUDING SYSTEMIC LUPUS (SLE), RHEUMATOID ARTHRITIS (RA), AND MULTIPLE SCLEROSIS. WE PROPOSE TO PRODUCE A PANEL OF HUMAN MONOCLONAL ANTI-DR (POLYMORPHIC) ALLOANTIBODIES. A HUMAN-MOUSE DERIVED MYELOMA LINE, SHOWN TO FUSE EFFICIENTLY TO HUMAN B CELLS AND PRODUCE STABLE HUMAN IMMUNOGLOBULIN-SECRETING HYBRIDOMAS, WILL BE FUSED TO B CELLS ISOLATED FROM NORMAL MULTIPAROUS WOMEN AND/OR TRANSFUSION RECIPIENTS KNOWN TO CONTAIN SPECIFIC ANTI-DR ANTIBODIES IN THEIR SERA. THE GENERATION OF THESE ANTIBODIES WILL ALLOW A GREATER UNDERSTANDING OF THEIR SPECIFICITY AND FUNCTIONAL EFFECTS ON IMMUNE FUNCTIONS OF NORMAL AND DISEASED INDIVIDUALS. ULTIMATELY, THESE ANTIBODIES MAY BE USEFUL IN THE DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISORDERS.

Principal Investigator:

Paul Wu
Principal Investigator
4155941600

Business Contact:

Small Business Information at Submission:

Gene Laboratorys, Inc.
871 Industrial Road, Building J San Carlos, CA 94070

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No