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MONOCLONAL ANTIBODIES TO HTLV-III/LAV

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4795
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4795
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NEUGENESIS CORPORATION
NEUGENESIS CORPORATION 871 INDUSTRIAL RD, STE J SAN CARLOS, CA 94070
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: MONOCLONAL ANTIBODIES TO HTLV-III/LAV
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

MOUSE AND RAT MONOCLONAL ANTIBODIES WILL BE PRODUCED AGAINSTHTLV-III, THE HUMAN RETROVIRUS ASSOCIATED WITH AIDS AND A SPECTRUM OF RELATED SYNDROMES. GENE LABS WILL EMPLOY INTACTHTLV-III VIRIONS COUPLED TO KLH AS AN IMMUNOGEN AND USE A SENSITIVE ELISA ASSAY, BASED ON PURIFIED HTLV-III AS THE ANTIGEN IN OUR PRIMARY SCREENING PROCEDURE. IMMUNOPRECIPI- TATION, WESTERN BLOTTING, AND CELLULAR IMMUNOFLUORESCENCE WILL BE USED TO CHARACTERIZE STABLE, IMMUNOGLOBULIN- SECRETING, ELISA-REACTIVE SUBCLONES. ANTIBODY BINDING CONSTANTS WILL BE ASSESSED BY STANDARD PROCEDURES. FINE MAPPING OF ANTIBODY SPECIFICITY AS IT CORRELATES WITH BIOLOGICAL EFFECTS WILL BE EXAMINED IN THE CONTEXT OF SEPARATE PHASE II FUNDING. PRELIMINARY STUDIES HAVE DEMONSTRATED THE FEASIBILITY OF THE PROPOSAL APPROACH, RESULTING IN THE GENERATION OF BOTH MOUSE AND RAT MONOCLONALANTIBODIES TO HTLV-III DETERMINED ANTIGENS. THE SUCCESSFUL COMPLETION OF THIS PROJECT WILL INVOLVE THE ESTABLISHMENT OFA COMPLETE PANEL OF RAT AND MOUSE MONOCLONAL ANTIBODIES WITHHIGH AVIDITY AGAINST EPITOPES THAT MAY BE WEAKLY IMMUNOGENICOR SILENT IN THE NORMAL HOST.

Principal Investigator:

Kou hwang
PRINCIPAL INVESTIGATOR
4155941600

Business Contact:

Small Business Information at Submission:

Gene Labs Inc
871 Industrial Road Building J San Carlos, CA 94070

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No