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THE GOAL OF THIS PROPOSED RESEARCH IS TO DEFINE THE MOLECU- LAR STRUCTURES THAT…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4981
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4981
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NEUGENESIS CORPORATION
NEUGENESIS CORPORATION 871 INDUSTRIAL RD, STE J SAN CARLOS, CA 94070
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE GOAL OF THIS PROPOSED RESEARCH IS TO DEFINE THE MOLECU- LAR STRUCTURES THAT DETERMINE THE ANTIGENETIC REACTIVITY OF THE HUMAN RH SYSTEM.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE GOAL OF THIS PROPOSED RESEARCH IS TO DEFINE THE MOLECU- LAR STRUCTURES THAT DETERMINE THE ANTIGENETIC REACTIVITY OF THE HUMAN RH SYSTEM. USING PREEXISTING HUMAN MONOCLONAL ANTIBODIES DIRECTED AGAINST A LARGE G DETERMINANT AND ONE DIRECTED AGAINST A DETERMINANT FOUND ON RH D+ CELLS BUT NOT DU CELLS, GENE LABS WILL REFINE THE CHARACTERIZATION OF THE HUMAN RH SYSTEM. IN ADDITION TO THE ABOVE ANTIBODIES, MORE ANTIBODIES DIRECTED AGAINST DETERMINANTS OF THE RH SYSTEM WILL BE MADE. THIS WILL BE DONE USING A HUMAN MYELOMA FUSION PARTNER TO IMMORTALIZE SENSITIZED LYMPHOCYTES OBTAINED FROM RH IMMUNE DONORS. THE GENES FOR THESE ANTI- BODIES WILL THEN BE MANIPULATED BY A VARIETY OF DNA CLONING TECHNIQUES TO INCREASE THE AFFINITY AND TO SWITCH THE ISOTYPES. AFTER SUCCESSFUL COMPLETION OF THE FIRST PHASE OFTHIS WORK, GENE LABS WILL EXTEND THE WORK TO PROVIDE A COMMERCIAL SUPPLY OF HUMAN MONOCLONAL ANTI-RH REAGENTS FOR BLOOD TYPING AND FOR THERAPY OF HEMOLYTIC DISEASE OF THE NEWBORN AND AUTOIMMUNE HEMOLYTIC ANEMIA.

Principal Investigator:

Kou m hwang
PRINCIPAL INVESTIGATOR
4155941600

Business Contact:

Small Business Information at Submission:

Gene Labs Inc
871 Industrial Road Building J San Carlos, CA 94070

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No