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THIS PROJECT WILL PRODUCE MOUSE AND RAT MONOCLONAL ANTIBODIES TO THE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4796
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4796
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NEUGENESIS CORPORATION
NEUGENESIS CORPORATION 871 INDUSTRIAL RD, STE J SAN CARLOS, CA 94070
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THIS PROJECT WILL PRODUCE MOUSE AND RAT MONOCLONAL ANTIBODIES TO THE LEUKEMOGENIC HUMAN RETROVIRUS, HTLV-I.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THIS PROJECT WILL PRODUCE MOUSE AND RAT MONOCLONAL ANTIBODIES TO THE LEUKEMOGENIC HUMAN RETROVIRUS, HTLV-I. STABLE, IMMUNOGLOBULIN-SECRETING HTLV-I ELISA-REACTIVE SUBCLONES WILL BE ISOLATED AND THEIR VIRAL ANTIGEN SPECIFICITY CONFIRMED BY IMMUNOPRECIPITATION, WESTERN BLOTTING, AND IMMUNOFLUORESCENCE ANALYSIS. THE BINDING CONSTANTS OF THE ANTIBODIES PRODUCED WILL BE DETERMINED. ITIS ANTICIPATED THAT IN A PHASE II PROJECT, FINE SPECIFICITY MAPPING OF THE ANTIBODIES WILL BE PERFORMED AND THEIR BIOLOGICAL EFFECTS CHARACTERIZED. PRELIMINARY STUDIES, RESULTING IN THE SUCCESSFUL GENERATION OF A MURINE MONOCLONAL ANTIBODY TO AN HTLV-I ANTIGEN, HAVE ALREADY DEMONSTRATED THE FEASIBILITY OF THE PROPOSED APPROACH. SUCCESSFUL GENERATION OF HIGH AVIDITY MOUSE AND RAT MONOCLONALS SHOULD PROVIDE REAGENTS WITH IMPROVED DIAGNOSTICPOTENTIAL AND POSSIBLE THERAPEUTIC UTILITY.

Principal Investigator:

Kou hwang
PRINCIPAL INVESTIGATOR
4155941600

Business Contact:

Small Business Information at Submission:

Gene Labs Inc
871 Industrial Road Building J San Carlos, CA 94070

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No