DESCRIPTION (provided by applicant): We will develop a set of statistical techniques that improve the prediction of the response of mutated Human Immunodeficiency Virus Type 1 (HIV-1) to anti-retroviral therapy. These techniques will have applicability to a wide array of clinical decisions beyond… More

DESCRIPTION (provided by applicant): The mission of the Gene Security Network (GSN) is to create a system that enables clinicians to use aggregated genetic and phenotypic data from clinical trials and treatment records to make the safest, most effective treatment decisions for each patient. A… More

DESCRIPTION (provided by applicant): In the process of pre-implantation genetic diagnoses (PGD), a single blastomere is removed from the early stage embryo for analysis. Currently, most PGD techniques focus on detection of chromosomal abnormalities such as aneuploidies and balanced translocations.1… More

DESCRIPTION (provided by applicant): In 2006, across the globe, more than 800,000 in-vitro fertilization (IVF) cycles were run. Of 150,000 cycles run in the US, roughly 10,000 involved pre-implantation genetic diagnosis (PGD). Current PGD techniques are un regulated, expensive and highly unreliable:… More

DESCRIPTION (provided by applicant): In each IVF cycle, a decision must be made as to which embryo(s) will be selected for transfer. This decision has a far reaching impact on the outcome of an IVF cycle, namely whether the embryo will develop into a healt hy child. It is estimated that at least 50%… More

DESCRIPTION (provided by applicant): In each IVF cycle, a decision must be made as to which embryo(s) will be selected for transfer. This decision has a far reaching impact on the outcome of an IVF cycle, namely whether the embryo will develop into a healthy child. It is estimated that at least 50%… More

DESCRIPTION (provided by applicant): During the course of a pregnancy, physicians and patients desire as much information as possible regarding the health of the fetus. For both emotional and medical reasons, this information is sought as early in term as possible, and with the fewest possible… More

DESCRIPTION (provided by applicant): During the course of a pregnancy, physicians and patients desire as much information as possible regarding the health of the fetus. For both emotional and medical reasons, this information is sought as early in term aspossible, and with the fewest possible risks… More