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SBIR PHASE I: A Technology that Improves Gene Targeting

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
88252
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
0740278
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
GENEPROTECH,INC.
9103 LAWN AVE ST. LOUIS, MO 63144-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: SBIR PHASE I: A Technology that Improves Gene Targeting
Agency: NSF
Contract: 0740278
Award Amount: $100,000.00
 

Abstract:

This Small Business Innovation Research (SBIR) Phase I research project aims to improve the frequency of homologous recombination by increasing the number of targeting vector molecules that reach the nucleus. The technology is based on constructing targeting vectors that have proteins involved in nuclear translocation attached. Recombination events that can target an exogenous DNA constructs to a particular gene are relatively rare due to a variety of reasons, one of the most important of which is the low frequency of transport across the nuclear membrane. Thus, an approach based on the use of members of a cell's own nuclear translocation machinery is likely to improve the odds of successful recombination events. Important therapeutic modalities such as gene therapy are dependent upon the efficient targeting of specific chromosomal loci. Development of methodologies that enhance nuclear targeting would improve the odds of successful recombination events and as such would not only be important for gene therapy, but also for the creation of novel animal models, which is also dependant on homologous recombination.

Principal Investigator:

Uthayashanker R. Ezekiel
PhD
3145835441
uezekiel@geneprotech.com

Business Contact:

Uthayashanker R. Ezekiel
PhD
3145835441
uezekiel@geneprotech.com
Small Business Information at Submission:

GENEPROTECH,INC.
9103 LAWN AVENUE St Louis, MO 63144

EIN/Tax ID: 010547942
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No