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REPRODUCIBILITY OF MOUSE LYMPHOMA MUTAGENESIS ASSAY RESULTS.

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3154
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3154
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Genesys Research, Inc.
2300 ENGLERT DR Durham, NC 27514
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: REPRODUCIBILITY OF MOUSE LYMPHOMA MUTAGENESIS ASSAY RESULTS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO DETERMINE WHETHER VARIABILITY IN MUTATION FREQUENCY RATIOS BETWEEN EXPERIMENTS IS COMPOUND SPECIFIC OR THE RESULT OF VARIABILITY IN TESTING CONDITIONS AND TO DETERMINE WHETHER COLONY SIZE DISTRIBUTIONS ARE A GOOD INDEX OF VARIABILITY OR SIMILARITY OF TESTING CONDITIONS. IN ORDER TO DEMONSTRATE THE FEASIBILITY OF THIS RESEARCH AND THE LABORATORY'S CAPABILITIES, PHASE I EFFORTS WILL BE DIRECTED PRIMARILY TOWARD DETERMINING COLONY SIZE DISTRIBUTIONS IN MOUSE LYMPHOMA TESTS OF 6 CHEMICALS MUTAGENIC IN THE MLA BUT NEGATIVE IN THE CHINESE HAMSTER OVARY (CHO) CHROMOSOMAL ABERRATION ASSAY. THESE RESULTS WILL BE COMPARED WITH THE RESULTS FROM ASSAYS FOR CHROMOSOMAL ABERRATIONS IN ML AND CHO CELLS TO DETERMINE WHETHER RATIOS OF TREATED TO SOLVENT CONTROL MUTATION FREQUENCIES VARY IN THE SAME MANNER AS RATIOS OF THE NUMBER OF CHROMOSOMAL ABERRATIONS IN TREATED VERSUS SOLVENT CONTROL SAMPLES.

Principal Investigator:

Ann d. mitchell
PRINCIPAL INVESTIGATOR
4159683635

Business Contact:

Small Business Information at Submission:

Genesys Research, Inc.
2224 Old Middlefield Way, Suit E C Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No