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REPRODUCIBILITY OF MOUSE LYMPHOMA MUTAGENESIS ASSAY RESULTS.
- Small Business Information
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Woman-Owned: YesMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 1985Title: REPRODUCIBILITY OF MOUSE LYMPHOMA MUTAGENESIS ASSAY RESULTS.Agency: HHSContract: N/AAward Amount: $50,000.00
Abstract:
IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO DETERMINE WHETHER VARIABILITY IN MUTATION FREQUENCY RATIOS BETWEEN EXPERIMENTS IS COMPOUND SPECIFIC OR THE RESULT OF VARIABILITY IN TESTING CONDITIONS AND TO DETERMINE WHETHER COLONY SIZE DISTRIBUTIONS ARE A GOOD INDEX OF VARIABILITY OR SIMILARITY OF TESTING CONDITIONS. IN ORDER TO DEMONSTRATE THE FEASIBILITY OF THIS RESEARCH AND THE LABORATORY'S CAPABILITIES, PHASE I EFFORTS WILL BE DIRECTED PRIMARILY TOWARD DETERMINING COLONY SIZE DISTRIBUTIONS IN MOUSE LYMPHOMA TESTS OF 6 CHEMICALS MUTAGENIC IN THE MLA BUT NEGATIVE IN THE CHINESE HAMSTER OVARY (CHO) CHROMOSOMAL ABERRATION ASSAY. THESE RESULTS WILL BE COMPARED WITH THE RESULTS FROM ASSAYS FOR CHROMOSOMAL ABERRATIONS IN ML AND CHO CELLS TO DETERMINE WHETHER RATIOS OF TREATED TO SOLVENT CONTROL MUTATION FREQUENCIES VARY IN THE SAME MANNER AS RATIOS OF THE NUMBER OF CHROMOSOMAL ABERRATIONS IN TREATED VERSUS SOLVENT CONTROL SAMPLES.Small Business Information at Submission:Principal Investigator:
Ann d. mitchell
PRINCIPAL INVESTIGATOR
4159683635Business Contact:
Genesys Research, Inc.
2224 Old Middlefield Way, Suit E C Mountain View, CA 94043EIN/Tax ID:DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 3154 |
Program Year/Program: 1985 / SBIR |
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Agency Tracking Number: 3154 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |