Trichothecene mycotoxinw by several genera of fungi and cause serious illness and death in animals and humans. these toxins sometimes occur naturally in the environment and aicultural prod. current methods in thericothecenes are highly specialized, laborious proceduresit is proposed to purs the dev-… More

The cyclic nucleotides, camp and cgmp are important regulatory molecules that are now recognized as mediators in a vast number of normal and pathological processes. such insights have increased the need for generally available technology that will allow the convenient and accurate measurement of the… More

Recent studies in many laboratories have demonstrated the presence of 2 ubiquitous, closely related enzymes, the calcium-activated proteases (cap i and ii). in brain, the cap enzymes act on neurofilament proteins and lead to the degradation of these neuronal components. the neurofilament proteins… More

Recent advances in biochemistry and immunology now make possible new approaches for detection and treatment of infectious diseases. our group is committed to such technological applications, and this phase i proposal is in response to the stated interest of the n.i.a.d.a. in such innovative… More

As the use of marihuana has continued to grow, the need for accurate and reliable means of measuring cannabinoid levels has become more urgent. this phase i application outlines our interest in developing such a cannabinoid assay which will be rapid, non-isotopic, and capable of being performed in a… More

Drug abuse has created a continuing need for a rapid and accurate system for the detection of amphetamines. this sbir proposal addresses the need for a rapid and specific enzyme-linked immunosorbent assay (elisa) for amphetamines which can be performed with only modest laboratory facilities. since… More