You are here

THE CYCLIC NUCLEOTIDES, CAMP AND CGMP ARE IMPORTANT REGULATORY MOLECULES THAT ARE NOW RECOGNIZED AS MEDIATORS IN A VAST NUMBER OF NORMAL AND PATHOLOGICAL PROCESSES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 1353
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1984
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
160 Community Drive
Great Neck, NY 11021
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 DR. HARVEY BRANDWEIN
 DIRECTOR
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE CYCLIC NUCLEOTIDES, CAMP AND CGMP ARE IMPORTANT REGULATORY MOLECULES THAT ARE NOW RECOGNIZED AS MEDIATORS IN A VAST NUMBER OF NORMAL AND PATHOLOGICAL PROCESSES. SUCH INSIGHTS HAVE INCREASED THE NEED FOR GENERALLY AVAILABLE TECHNOLOGY THAT WILL ALLOW THE CONVENIENT AND ACCURATE MEASUREMENT OF THE CYCLIC NUCLEOTIDES IN RESEARCH AND CLINICAL SETTINGS. THIS PHASE I PROPOSAL OUTLINES OUR INTEREST IN PURSUING THE GENERATION OF MURINE MONOCLONAL ANTI CAMP/CGMP ANTIBODIES AND FLUORESCENT ENZYME IMMUNOASSAY SYSTEMS FOR THE RAPID AND SENSITIVE MEASUREMENT OF THE CYCLIC NUCLEOTIDES IN BIOLOGICAL MATERIALS. HYBRIDOMAS WILL BE PREPARED VIA FUSION OF MOUSE MYELOMA CELLS WITH SPLEENS OF MICE IMMUNIZED WITH SUCCINYL-CAMP (OR CGMP) CONJUGATED TO BOVINE SERUM ALBUMIN. RESULTANT MONOCLONAL ANTIBODIES WILL BE ATTACHED TO BETA-GALACTOSIDASE AND UTILIZED IN A RAPID SOLID-PHASE ENZYME IMMUNOASSAY USING FLUOROGENIC SUBSTRATES. THESE EXPECTED RESULTS WILL SERVE AS THE BASIS OF PHASE II, WHERE WE ENVISION THAT THE FINAL ASSAY FORMAT DEVELOPED WILL OFFER VALUABLE AND NOVEL TOOLS FOR BASIC RESEARCH. ADDITIONALLY, WE BELIEVE THAT SUCH PRODUCTS WILL HAVE SIGNIFICANT COMMERCIAL MARKETS IN RESEARCH AND CLINICAL MEDICINE, AND MAY OFFER NEW DIAGNOSTIC AIDS FOR THE EARLY DETECTION OF SEVERAL DISEASE AND NEOPLASTIC CONDITIONS.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government