USA flag logo/image

An Official Website of the United States Government

Creating a Female Non-Insulin Dependent Diabetic Rat

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22200
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
22200
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Genetic Models, Inc.
8501 Zionsville Road Indianapolis, IN 46268
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Creating a Female Non-Insulin Dependent Diabetic Rat
Agency: HHS
Contract: N/A
Award Amount: $745,661.00
 

Abstract:

Our objective is to create a female rat model which exhibits Non-Insulin Dependent Diabetes Mellitus (NIDDM). Literature supports that our diabetic, fatty male rat as superior to other available rat models in the onset and level of diabetes expressed. Characteristics such as pancreatic insulin release and muscle insulin resistance appear to mimic the human condition. Significant growth in the use of the male (ZDF/Gmi, fa/fa) by researchers has occurred since the model's commercial availability. Preliminary experimentation lead us to believe, that through manipulation of diet, NIDDM can be produced in the ZDF/Gmi female. Currently, there is no reliable type II female model available for comparative study. Considering that the ZDF/Gmi female has not historically expressed NIDDM, and the preliminary data shows that these same females have expressed high glucose levels through carbohydrate stimulation, it is believed that a female NIDDM model can be created. Through experimental dietary manipulation the research team believes both the degree and the timing of onset of NIDDM in this model can be made both reliable and variable. Based upon current input from the researchers utilizing the male model, the creation of the female would be well received.

Principal Investigator:

Leah A. Little
3178247070

Business Contact:

Small Business Information at Submission:

Genetic Models, Inc.
8501 Zionsville Road Indianapolis, IN 46268

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No