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Company Information:

Company Name: GENTEST CORPORATION
City: Woburn
State: MA
Zip+4: 01801
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $544,522.00 8
SBIR Phase II $2,261,761.00 6

Award List:

COMPARISON OF GENE MUTATION ASSAYS IN HUMAN LYMPHOBLASTOID A

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bruce W. Penman , Principal Investigator
Award Amount: $49,636.00

COMPARISON OF GENE MUTATION ASSAYS IN HUMAN LYMPHOBLASTOID A

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: HHS
Principal Investigator: Bruce W. Penman , Principal Investigator
Award Amount: $150,000.00
Abstract:
We propose to use a gene mutation assay at the thymidine kinase locus in tk6 human lymphoblasts to evaluate the mutagenicity of chemicals which have been found to be mutagenic in mouse lymphoma l5178y cells. the tk6 cell mutation assay protocol has been designed to minimize differences with the… More

THE DEVELOPMENT OF CELL LINES EXPRESSING RAT CYTOCHROME P450CDNAS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles L Crespi
Award Amount: $49,649.00

THE DEVELOPMENT OF CELL LINES EXPRESSING RAT CYTOCHROME P450CDNAS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator: Charles L Crespi
Award Amount: $343,945.00
Abstract:
This project will develop human cell lines expressing rat cytochrome p450 cdnas. two rat cytochrome p450 cdnas, encoding p450iib1 and p450iid1, will be transfected into theahh-1 tk+/- line of human lymphoblastoid cells. vectors containing the epstein-barr virus origin of replication will be used in… More

SBIR TOPIC NUMBER 021 DEVELOPMENT OF HUMAN CELL LINES

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles Crespi , Principal Investigator
Award Amount: $49,949.00

SBIR TOPIC NUMBER 021 DEVELOPMENT OF HUMAN CELL LINES

Award Year / Program / Phase: 1992 / SBIR / Phase II
Agency: HHS
Principal Investigator: Charles Crespi , Principal Investigator
Award Amount: $423,644.00

DEVELOPMENT OF SYSTEM TO DETECT PEROXISOME PROLIFERATORS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bruce W Penman
Award Amount: $46,599.00

DEVELOPMENT OF SYSTEM TO DETECT PEROXISOME PROLIFERATORS

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Bruce W Penman
Award Amount: $398,948.00
Abstract:
We will develop a novel system for detecting chemicals which induce peroxisome proliferation. this system will consist of a human cell line which has been transfected with specific receptor and reporter gene constructs. cells will be transfected with chimeric receptors containing the ligand binding… More

Development of Methods for Cytochrome P450 Production

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bruce W. Penman
Award Amount: $48,689.00
Abstract:
We will develop and optimize methods for high level production of functional, catalytically active human cytochrome P450s by using baculovirus expression in insect cells. Approaches to maximize production of holoenzyme and minimize production of apoprotein will be developed and means to efficiently… More

Overexpression of Xenobiotic Metabolizing Enzymes

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Vaughn Miller
Award Amount: $100,000.00

Development of Caco-2 Cells Expressing Cytochromes P450

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Charles Crespi
Award Amount: $100,000.00

Overexpression of Xenobiotic Metabolizing Enzymes

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Vaughn Miller
Award Amount: $455,626.00
Abstract:
The plan is to develop and optimize a method for high level production of functional, catalyticallycytochromes P450 using baculovirus expression in insect cells. Cytochromes P450 are the principal enmetabolism of many drugs, protoxins, and environmental pollutants. This proposed method includes… More

Development of Caco-2 Cells Expressing Cytochromes P450

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Charles Crespi
Award Amount: $489,598.00
Abstract:
We will evaluate the feasibility of expressing human cytochrome P450 (CYP) cDNAs in Caco-2 human inepithelial cells, a model system for the study of drug/xenobiotic uptake and transport. Expression susing CYP2A6 as a convenient and appropriate model enzyme and then extended to CYP3A4, the major… More

IN VITRO SYSTEMS TO STUDY BILIARY TRANSPORT

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Crespi, Charles L
Award Amount: $100,000.00