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Development of Methods for Cytochrome P450 Production

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22215
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22215
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
GENTEST CORPORATION
6 HENSHAW ST Woburn, MA 01801
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Development of Methods for Cytochrome P450 Production
Agency: HHS
Contract: N/A
Award Amount: $48,689.00
 

Abstract:

We will develop and optimize methods for high level production of functional, catalytically active human cytochrome P450s by using baculovirus expression in insect cells. Approaches to maximize production of holoenzyme and minimize production of apoprotein will be developed and means to efficiently co-express cytochrome P450:NADPH oxidoreductase will be developed. Human cytochromes P4502A6 and P4502E1 will be used as prototype enzymes for this development. The eventual goal is to develop a complete panel expressing high levels of individual human cytochrome P450 forms. The commercial applications will be for the study of human xenobiotic metabolism.

Principal Investigator:

Bruce W. Penman
6179355115

Business Contact:

Small Business Information at Submission:

Gentest Corp.
6 Henshaw Street Woburn, MA 01801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No