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Development of Caco-2 Cells Expressing Cytochromes P450

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29450
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
29450
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
GENTEST CORPORATION
6 HENSHAW ST Woburn, MA 01801
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1997
Title: Development of Caco-2 Cells Expressing Cytochromes P450
Agency: HHS
Contract: 1 R43 GM52270-01,
Award Amount: $489,598.00
 

Abstract:

We will evaluate the feasibility of expressing human cytochrome P450 (CYP) cDNAs in Caco-2 human inepithelial cells, a model system for the study of drug/xenobiotic uptake and transport. Expression susing CYP2A6 as a convenient and appropriate model enzyme and then extended to CYP3A4, the major cytin human intestinal epithelium. The suitability of transfected cells for studies of xenobiotic transThe overall goal is to develop Caco-2 cell derivatives which express the human cytochrome P450s founvivo in order to establish a better in vitro model system for drug transport / metabolism and for detherapeutically relevant drug-drug or drug-nutrient interactions.

Principal Investigator:

Charles Crespi
61735

Business Contact:

Small Business Information at Submission:

Gentest Corp.
6 Henshaw Street Woburn, MA 01801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No