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High Throughput Genomics Screening for Malaria Antigen Discovery

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
73714
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
A043-189-0667
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
GENVEC, INC.
910 Clopper Road  Suite 220N GAITHERSBURG, MD 20878
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: High Throughput Genomics Screening for Malaria Antigen Discovery
Agency / Branch: DOD / ARMY
Contract: W81WXH-05-C-0108
Award Amount: $69,993.00
 

Abstract:

Malaria is a major threat to world health and the personnel of the US armed forces. To date there is no available effective protective vaccine. However, an abundance of data in animal models and in humans has indicated the existence of protective antigens and demonstrated that an effective vaccine against malaria is feasible. Unfortunately, the most effective vaccine, based on radiation attenuated Plasmodium falciparum sporozoites, is not practical for mass use. The overall goal of this proposal is to develop a technology that can identify and prioritize novel protective target antigens for vaccine development. Our hypothesis is that P. yoelii antigens that are recognized by irradiated sporozoite immunized mice can be identified using an in vitro system and that such antigens will elicit strong protective immune responses when delivered in a potent vaccine. Furthermore, the corresponding P. falciparum orthologues will be excellent vaccine candidates. The phase I SBIR focuses on the feasibility of the screen; objective #1 focuses on methods to generate antigen carrying vectors, objective #2 focuses on the assays to identify T-cells specificities from immune animals, and objective #3 focuses on the use of proprietary adenoviral targeting technology to improve the sensitivity and through-put of the screen.

Principal Investigator:

Joseph Bruder
Director, Vaccines and Vector Progr
2406325543
jbruder@genvec.com

Business Contact:

C. Richter King
Vice President, Research
2406325537
rking@genvec.com
Small Business Information at Submission:

GENVEC, INC.
65 W. Watkins Mill Road Gaithersburg, MD 20878

EIN/Tax ID: 232705690
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No