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THE ULTIMATE GOAL OF THE PROGRAM IS TO DEVELOP A PRACTICAL MICROELECTRODE WHICH…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
478
Program Year/Program:
1983 / SBIR
Agency Tracking Number:
478
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Giner, Inc.
89 Rumford Avenue Newton, MA 02466-1311
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1983
Title: THE ULTIMATE GOAL OF THE PROGRAM IS TO DEVELOP A PRACTICAL MICROELECTRODE WHICH IS CAPABLE OF RELIABLY MEASURING LOCAL CARBON DIOXIDE AND OXYGEN TENSIONS CONCURRENTLY, IN TISSUE AND BODY FLUIDS.
Agency: HHS
Contract: N/A
Award Amount: $49,949.00
 

Abstract:

THE ULTIMATE GOAL OF THE PROGRAM IS TO DEVELOP A PRACTICAL MICROELECTRODE WHICH IS CAPABLE OF RELIABLY MEASURING LOCAL CARBON DIOXIDE AND OXYGEN TENSIONS CONCURRENTLY, IN TISSUE AND BODY FLUIDS. CONTINUOUS IN-SITU MONITORING OF PCO(2) AND PO(2) CAN HAVE SIGNIFICANT IMPACT IN INTENSIVE CARE, OPERATING ROOMS, AND RESEARCH LABORATORIES. THE PRINCIPAL APPLICATIONS OF SUCH A DEVICE INCLUDE MANAGEMENT OF VENTILATION, ACID-BASE BALANCE, AND BASIC RESEARCH. THE PCO(2) MEASUREMENT IS BASED ON THE QUANTITATIVE DETERMINATION OF THE AMOUNT OF "REDUCED-CO(2)" ABSORBED ON THE PT-BASED WORKING ELECTRODE. PO(2) IS OBTAINED BY MEASURING THE O(2) REDUCTION LIMITING CURRENT IN A WELL DEFINED POTENTIAL REGION. THE PCO(2) AND PO(2) MEASUREMENTS CAN BE MADE AT A HIGH SAMPLING RATE WITHOUT MUTUAL INTERFERENCE. THE PROPOSED MICROELECTRODE IS A FINE WIRE ELECTRODE (E.G. 25 MICRONS IN DIAMETER) WITH A SHARP TIP. GASES TO BE MEASURED PERMEATE THROUGH THE HYDROPHOBIC MEMBRANE COVERING THE TIP AND EQUILIBRATE WITH ELECTROLYTE BEHIND THIS HYDROPHOBIC LAYER. THE WORK PLANNEDIN PHASE I WILL BE CARRIED OUT IN TWO ITERATIVE STAGES. THEFIRST STAGE INVOLVES THE FABRICATION AND EVALUATION OF MICROELECTRODES IN A NUMBER OF PRELIMINARY CONFIGURATIONS. IN THE SECOND STAGE, A FEW ELECTRODES WILL BE FABRICATED USING THE MOST PROMISING CONSTRUCTION DESIGN TO FURTHER REFINE THEIR OPERATING PARAMETERS.

Principal Investigator:

David k. wong
PRINCIPAL INVESTIGATOR
6178997270

Business Contact:

Small Business Information at Submission:

Giner Inc.
14 Spring Street Waltham, MA 02154

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No