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ARTIFICIAL NERVE GRAFT FOR PERIPHERAL NERVE REPAIR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16765
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16765
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
GLIATECH, INC.
GLIATECH, INC. 23420 COMMERCE PARK RD CLEVELAND, OH 44122
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: ARTIFICIAL NERVE GRAFT FOR PERIPHERAL NERVE REPAIR
Agency: HHS
Contract: N/A
Award Amount: $49,302.00
 

Abstract:

THIS PROJECT'S OBJECTIVE IS TO DEVELOP AN ARTIFICIAL NERVE GRAFT FOR REPAIR OF PERIPHERAL NERVE INJURIES. THIS GRAFT WILL CONSIST OF THE PATIENT'S OWN SCHWANN CELLS SEEDED INTO A POLYMER TUBE TO BE IMPLANTED INTO NERVE GAPS. THIS PRODUCT WILL AID IN RESTORING NEUROLOGICAL FUNCTION FOR THE APPROXIMATELY 300,000 AMERICANS EACH YEAR WHO SUFFER PERIPHERAL NERVE INJURY. THE SPECIFIC AIMS AND METHODOLOGY ARE: (I) TO ESTABLISH CULTURES OF ADULT SCHWANN CELLS BY THE SEQUENTIAL EXPLANATION METHOD. (II) TO RAPIDLY PURIFY AND EXPAND THESE CULTURES BY AN IMMUNOSELECTION TECHNIQUE. (III) TO SHOW THE ABILITY OF THE ARTIFICIAL NERVE GRAFT TO PROMOTE AXONAL REGENERATION ACROSS A 2 CM NERVE GAP. PURIFIED ADULTSCHWANN CELLS WILL BE SEEDED INTO SEMI-PERMEABLE POLYMER TUBES, WHICH ARE IMPLANTED INTO A 2 CM GAP OF RAT SCIATIC NERVE. AXONAL REGENERATION WILL BE MEASURED BY HISTOLOGICALMETHODS. (IV) TO SHOW AN INCREASE IN SPEED OF NEUROLOGICAL RECOVERY BY ELECTROPHYSIOLOGICAL AND BEHAVIORAL METHODS. AN ARTIFICIAL NERVE GRAFT WILL PROVIDE A NEW AND EFFECTIVE METHOD FOR BRIDGING NERVE GAPS AND ACHIEVING RELIABLE NEUROLOGICAL RECOVERY. IN PHASE I, THE PROOF OF CONCEPT WILL BE ESTABLISHED AND IN PHASE II, THE DESIGN FOR THE ARTIFICIAL NERVE GRAFT WILL BE OPTIMIZED. THIS PROJECT'S OBJECTIVE IS TO DEVELOP AN ARTIFICIAL NERVE GRAFT FOR REPAIR OF PERIPHERAL NERVE INJURIES. THIS GRAFT WILL CONSIST OF THE PATIENT'S OWN SCHWANN CELLS SEEDED INTO A POLYMER TUBE TO BE IMPLANTED INTO NERVE GAPS. THIS PRODUCT WILL AID IN RESTORING NEUROLOGICAL FUNCTION FOR THE APPROXIMATELY 300,000 AMERICANS EACH YEAR WHO SUFFER PERIPHERAL NERVE INJURY. THE SPECIFIC AIMS AND METHODOLOGY ARE: (I) TO ESTABLISH CULTURES OF ADULT SCHWANN CELLS BY THE SEQUENTIAL EXPLANATION METHOD. (II) TO RAPIDLY PURIFY AND EXPAND THESE CULTURES BY AN IMMUNOSELECTION TECHNIQUE. (III) TO SHOW THE ABILITY OF THE ARTIFICIAL NERVE GRAFT TO PROMOTE AXONAL REGENERATION ACROSS A 2 CM NERVE GAP. PURIFIED ADULTSCHWANN CELLS WILL BE SEEDED INTO SEMI-PERMEABLE POLYMER TUBES, WHICH ARE IMPLANTED INTO A 2 CM GAP OF RAT SCIATIC NERVE. AXONAL REGENERATION WILL BE MEASURED BY HISTOLOGICALMETHODS. (IV) TO SHOW AN INCREASE IN SPEED OF NEUROLOGICAL RECOVERY BY ELECTROPHYSIOLOGICAL AND BEHAVIORAL METHODS. AN ARTIFICIAL NERVE GRAFT WILL PROVIDE A NEW AND EFFECTIVE METHOD FOR BRIDGING NERVE GAPS AND ACHIEVING RELIABLE NEUROLOGICAL RECOVERY. IN PHASE I, THE PROOF OF CONCEPT WILL BE ESTABLISHED AND IN PHASE II, THE DESIGN FOR THE ARTIFICIAL NERVE GRAFT WILL BE OPTIMIZED.

Principal Investigator:

Jerome Wujek
2168313200

Business Contact:

Small Business Information at Submission:

Gliatech Inc
23420 Commerce Park Rd Beachwood, OH 44122

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No