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AN EFFICIENT METHOD FOR GENERATING FULL-LENGTH CDNA

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7225
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7225
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Gold Biotechnology Inc
7166 Manchester Road St Louis, MO 63143
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: AN EFFICIENT METHOD FOR GENERATING FULL-LENGTH CDNA
Agency: HHS
Contract: N/A
Award Amount: $42,000.00
 

Abstract:

GOLD BIOTECHNOLOGY, INC. IS STUDYING A NEW METHOD FOR GENERATING FULL-LENGTH CDNA. THIS METHOD SHOULD BE SIMPLE AND EFFICIENT AND THUS ALLOW CLONING OF BOTH RARE AND ABUNDANT MRNA. THIS METHOD IMPROVES UPON OTHER PROCEDURES IN THE FOLLOWING WAYS: (1) NO S1 NUCLEASE IS REQUIRED FOR CLONING CDNA INTO THE VECTOR, AND (2) TAILING OF CDNA IS UNNECESSARY FOR BOTH INSERTION OF THE CDNA INTO THE VECTOR AND CIRCULARIZATION OF CDNA VECTOR HYBRID. THE SYNTHESIS OF FULL-LENGTH CDNA CAN BE EXPLOITED TO PRODUCE IMPORTANT COMMERCIAL PRODUCTS. THESE INCLUDE MATERIALS SUCH AS GROWTH FACTORS, HORMONES, AND IMMUNOREGULATORY MOLECULES. IN ADDITION TO DIRECT COMMERCIAL PRODUCTS, THERAPEUTIC USE OF FULL-LENGTH CDNAS MAY BECOME IMPORTANT AS ANTISENSE MRNA TECHNOLOGIES ARE IMPROVED. THIS PROJECT WILL DEMONSTRATE THE SUPERIORITY OF THE PROPOSED CDNA METHOD USING GLOBIN MRNA, A HOMOGENEOUS TEMPLATE.

Principal Investigator:

Paul gold phd
3145347609

Business Contact:

Small Business Information at Submission:

Gold Biotechnology Inc
5050 Oakland Avenue St Louis, MO 63110

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No