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THIS RESEARCH PROJECT AIMS TO DEVELOP A CLINICAL DEVICE TO MEASURE CORNEAL…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4919
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4919
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Greenmark Inc
Suite 721 Golf Mill Prof Bldg 9411 Greenwood Drive Niles, IL 60648
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THIS RESEARCH PROJECT AIMS TO DEVELOP A CLINICAL DEVICE TO MEASURE CORNEAL OXYGEN CONSUMPTION NONINVASIVELY.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THIS RESEARCH PROJECT AIMS TO DEVELOP A CLINICAL DEVICE TO MEASURE CORNEAL OXYGEN CONSUMPTION NONINVASIVELY. THE DEVICE WILL OPERATE BY MEASURING THE RATE OF DECREASE OF THEOXYGEN TENSION IN A MEMBRANE RESERVOIR APPLIED BRIEFLY TO THE CORNEA. MATHEMATICAL NALAYSIS OF THE RESULTING DATA WILL GIVE OXYGEN CONSUMPTION IN THE COMPONENT LAYERS OF THE CORNEA. THE AIMS OF THIS PHASE I RESEARCH ARE TO ESTABLISH THE TECHNICAL MERIT AND FEASIBILITY OF THE OPERATING PRINCI-PLES OF THE MONITOR. PHASE II WILL LEAD TO THE DEVELOPMENT OF A PROTOTYPE OXYGEN CONSUMPTION MONITOR FOR COMMERCIAL APPLICATION. THE ULTIMATE GOAL IS TO HAVE SUCH A DEVICE GENERALLY AVAILABLE FOR CLINICAL PROCEDURES SUCH AS CORNEAL MEASUREMENTS TO EVALUATE THE MOST APPROPRIATE CONTACT LENS MATERIAL, ESPECIALLY FOR EXTENDED WEAR LENSES. PHASE I AIMSARE GROUPED IN THREE MAIN CATEGORIES: . DEVELOPMENT OF MATHEMATICAL MODELS TO BE USED IN THE THEORETICAL TREATMENT OF THE MEASURED RATE OF OXYGEN TENSION (PO2) DECREASE RECORDED FOLLOWING APPLICATION OF THE SENSOR TO THE CORNEA. . MODIFICATION OF AN EXISTING POLAROGRAPHIC OXYGEN ELEC- TRODE TO A PREPROTOTYPE OXYGEN UPTAKE SENSOR. THE MAIN FEATURE WILL BE THE ISOLATION OF THE CORNEA FROM THE ELECTRODE BY AN INTERVENING OXYGEN RESERVOIR MEMBRANE. . TESTING AND EVALUATION OF THE PREPROTOTYPE IN VITRO AND USING RABBIT CORNEAS TO DETERMINE ITS ENGINEERING AND PHYSIOLOGICAL FEASIBILITY.

Principal Investigator:

Brian w brandell
PRINCIPAL INVESTIGATOR
3122984440

Business Contact:

Small Business Information at Submission:

Greenmark Inc
Suite 721 Golf Mill Prof Bldg 9411 Greenwood Drive Niles, IL 60648

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No