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Bioluminescent Detection of Chemical Agent Contamination

Award Information

Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Award ID:
74339
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
05SB2-0411
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Guild Associates, Inc.
5750 Shier Rings Rd P.O. Box 8013 Dublin, OH 43016-2013
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Bioluminescent Detection of Chemical Agent Contamination
Agency / Branch: DOD / DARPA
Contract: W31P4Q-06-C-0067
Award Amount: $98,998.00
 

Abstract:

Chemical weapons such as organophosphate (OP) nerve agents pose a deadly risk to both military and civilian personnel as exemplified by the use of nerve agents during the Iran/Iraq war and the Tokyo terrorist subway attack of 1995 which caused over 3,000 casualties. In addition, OP pesticide contamination of soils and water supplies is thought to result in 1 to 3 million cases of pesticide poisonings annually worldwide. Consequently, there is an urgent need for natural biological systems that can detect and safely dispose of these toxic compounds. This proposal will generate a genetically engineered yeast biosensor that can detect and hydrolyze chemical warfare agents such as VX. Importantly, the yeast biosensor will also be able to detect the subsequent biodegraded products. The yeast Saccharomyces cerevisiae, which is a robust non-pathogenic microorganism that is resistant to environmental extremes, will be used as a self-contained biosensor. No exogenous substrates or consumables will be required and a simple hand held illumination device will allow distinct visual detection of the chemical agent contamination and biodegraded products using a dual fluorescent reporter system.

Principal Investigator:

David Schofield
Principle Investigator
8435730095
dschofield@guildassociates.com

Business Contact:

Marcie Willem
Program Administrator
6147988215
marcie@guildassociates.com
Small Business Information at Submission:

GUILD ASSOC., INC.
5750 Shier Rings Rd, P.O. Box 8013 Dublin, OH 43016

EIN/Tax ID: 310998683
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No