Foams are used in many industries, yet the mechanisms that control foam stability are not well understood. the decay of foam is controlled largely by ostwald ripening of large foam cells at the expense of small foam cells. the decay mechanism is complicated by gravitational effects. the use of a… More

The degradation in optical and mechanical properties of fibers caused by atmospheric water is a serious problem. little is known, however, of the types and quantities of water actually associated with optical fibers, and the mechanism for the deleterious effect of these states of water. this project… More

Surface tension is a fundamental property of all liquids. the surface tension of liquids during processing affects the properties of a variety of high performance materials, i.e.: alloys, ceramics, composites, and polycrystalline materials. surface tension is not routinely measured for most… More

Biodetection requires a recognition mechanism for the analyte of interest. Receptors not only provide this recognition mechanism, but also make possible generic detection, for example, neurotoxins can be recognized by a representative array of human neuroreceptors. A serious drawback with using… More

The development of a new instrument for synthesizing combinatorial libraries is proposed. Theinstrument, coined SCAMP, has the potential to synthesize peptide arrays containing millions of relatedpeptides. It will be highly automated, and thus find use by those unskilled in the use of… More

Not Available Innovative research and development leading to a dual-use advanced technology product is proposed. The product is a methodology and software for design and life prediction of ceramic matrix composite (CMC) engine components. The primary focus is on a Nicalon/SiC composite, which is… More

The overall objective of this research is to develop a new process and laboratory instrument capable of synthesizing microspots of vitrified immobilized proteins and ligands. Immobilized proteins and ligands stored in a vitrified (glassy) sugar matrix would be well preserved at room and even… More

DESCRIPTION (provided by applicant): The overall objective of this research is to develop a new process and laboratory instrument capable of synthesizing microspots of vitrified immobilized proteins and ligands. Immobilized proteins and ligands stored in a vitrified (glassy) sugar matrix would be… More

DESCRIPTION (provided by applicant): Microarrays are finding increasing use by researchers in a variety of fields. While DNA microarrays have found the largest application in research, there is increasing interest in microarrays consisting of antibodies and other proteins. The overall objective of… More

DESCRIPTION (provided by applicant): DNA microarray chips have proven to be a highly useful tool for studying the vast amounts of information generated in the genomics field. With the focus moving to proteomics, there is now significant interest in analogo us protein-analysis chips. Existing methods… More

DESCRIPTION (provided by applicant): If successful, this program will result in an assay chip that collects, stabilizes, and accurately quantifies a suite of biomarkers indicative of renal injury. Its sensitivity and accuracy may enable it to detect slowlyoccurring renal damage. Its multianalyte… More