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AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3125
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3125
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
H. G. Pars Pharmaceutical Labo
763 Concord Avenue Cambridge, MA 02138
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE. GOSSYPOL, THE MOST PROMISING NONSTEROIDAL MALE ANTIFERTILITY LEAD, HAS AN UNACCEPTABLY NARROW THERAPEUTIC RATIO. WE PROPOSE THAT THE THERAPEUTIC RATIO MAY BE IMPROVED BY ALTERATION OF THE PHARMACOKINETICS AND BIOAVAILABILITY THROUGH WATER-SOLUBILIZATION. ACCORDINGLY, SEVERAL CAREFULLY CHOSEN WATER-SOLUBLE DERIVATIVES OF GOSSYPOL WILL BE PREPARED. THESE COMPOUNDS WILL THEN BE TESTED FOR BOTH IN VITRO SPERMICIDAL ACTIVITY AND IN VIVO ANTIFERTILITY ACTIVITY. THE IN VIVO TESTS WILL BE EVALUATED BOTH IN TERMS OF EFFICACY AND TOXICITY. THE IDENTIFICATION OF A COMPOUND WITH THE SAME EFFICACY AS GOSSYPOL BUT WITHOUT THE TOXIC EFFECTS WOULD PROVIDE THE BASIS FOR FURTHER STUDY LEADING TO THE EVENTUAL

Principal Investigator:

Harry g. pars
PRINCIPAL INVESTIGATOR
6173542800

Business Contact:

Small Business Information at Submission:

H. G. Pars Pharmaceutical Labo
763 Concord Avenue Cambridge, MA 02138

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No