Currently, an assay to measure the rate of bone resorption in an easy and reproducible manner does not exist. osteocalcin, a bone-specific protein, is assayed as a marker of bone formation. since there is reasonable evidence that fragments of bone proteins are liberated by the resorptive process, an… More

Thrombosis and thrombolysis are maintained in a delicate balance by a series of enzymatic reactions. the component enzymes are produced as needed from zymogens, inactive forms that circulate in the blood at relatively high concentrations. identifying and evaluating patients at riskfor clinical… More

In the area of clinical coagulation research, much attention is focused on the molecular eventswhich occur before, during, and after anticoagulant and antithrombotic therapies. For purposes ofmonitoring the safety, efficacy and long-term effects of such therapies, there exist a number ofcommercially… More

Factors V and VIII are procofactors which are essential components of the blood coagulationprocess. Deficiency in either of these proteins is associated with severe bleeding disorders, hemophiliaand para-hemophilia. Deficiency states of these proteins can be caused by their proteolytic… More

DESCRIPTION (provided by applicant): The mechanisms that govern blood coagulation and fibrinolysis have been studied extensively by employing a variety of experimental techniques and in-vivo model systems. Recently gene targeting (knockout mice) and transgenic techniques have been employed to create… More

DESCRIPTION (provided by applicant): Factor Vlla and Tissue Factor (TF) are essential proteins for the initiation of blood coagulation. Blood coagulation is initiated when cryptic TF becomes exposed on the surface of vascular cells where it can bind circulating factor Vlla. The factor Vlla/TF… More

DESCRIPTION (provided by applicant): Although the vast majority of patients who suffer from venous or arterial thrombosis have haemostatic systems that fall within the "normal" range of routine screening tools such as PT, aPTT, and factor assays, thrombosis is the major cause of death in Western… More

DESCRIPTION (provided by applicant): The mechanisms that govern blood coagulation and fibrinolysis have been studied extensively by employing a variety of experimental techniques and in-vivo model systems. Recently gene targeting (knockout mice) and transgenic techniques have been employed to create… More

DESCRIPTION (provided by applicant): Factor VIIa and tissue factor (TF) are essential proteins for the initiation of blood coagulation. Blood coagulation is initiated when cryptic TF becomes exposed on the surface of vascular cells where it can bind circulating factor VIla. The factor Vlla/TF… More