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IMMUNOASSAY FOR OSTEOCALCIN FRAGMENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11116
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11116
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
HAEMATOLOGIC TECHNOLOGIES, INC.
HAEMATOLOGIC TECHNOLOGIES, INC. 57 RIVER RD ESSEX JUNCTION, VT 05452
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: IMMUNOASSAY FOR OSTEOCALCIN FRAGMENTS
Agency: HHS
Contract: N/A
Award Amount: $46,139.00
 

Abstract:

CURRENTLY, AN ASSAY TO MEASURE THE RATE OF BONE RESORPTION IN AN EASY AND REPRODUCIBLE MANNER DOES NOT EXIST. OSTEOCALCIN, A BONE-SPECIFIC PROTEIN, IS ASSAYED AS A MARKER OF BONE FORMATION. SINCE THERE IS REASONABLE EVIDENCE THAT FRAGMENTS OF BONE PROTEINS ARE LIBERATED BY THE RESORPTIVE PROCESS, AN ASSAY OF OSTEOCALCIN FRAGMENTS SHOULD ALLOW AN ASSESSMENT OF RESORPTION. THIS, WHEN COUPLED WITH ASSESSMENTS OF FORMATION, SHOULD ALLOW AN ESTIMATION OF OSTEOPOROTIC RISK. SINCE OSTEOPOROSIS IS A MAJOR HEALTH-CARE PROBLEM OF THE ELDERLY, SUCH AN ASSESSMENT WOULD BE WIDELY APPLIED. THE SPECIFIC AIMS OF THIS PROJECT ARE: (1) THE ISOLATION AND CHARACTERIZATION OF OSTEOCALCIN FRAGMENTS FROM SERUM, (2) THE PREPARATION OF SYNTHETIC PEPTIDES AND TRYPTIC FRAGMENTS FOR USE AS ANTIGENS, AND (3) THE PREPARATION OF A PANEL OF FRAGMENT-DIRECTED MONOCLONAL ANTIBODIES THAT MAY SERVE AS REAGENTS FOR THE DEVELOPMENT OF AN OSTEOCALCIN FRAGMENT IMMUNOASSAY.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Haematologic Technologies Inc
57 River Rd Box 1021 Essex Junction, VT 05452

EIN/Tax ID: 030312741
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No