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TIME-INTEGRATED MEASUREMENT OF HORMONE AVAILABILITY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
5341
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
5341
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Hammersmith Laboratories Inc
Po Box 774324 Steamboat Springs, CO 80477
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: TIME-INTEGRATED MEASUREMENT OF HORMONE AVAILABILITY
Agency: HHS
Contract: N/A
Award Amount: $488,000.00
 

Abstract:

THE PURPOSE OF THIS RESEARCH IS PRODUCTION AND TESTING OF A NEEDLE-IMPLANTABLE DEVICE FOR ESTIMATING LONG-TERM TISSUE AVAILABILITY OF THE HORMONE CORTICOSTERONE IN RATS. THIS WORK CONTRIBUTES TO THE LONG-TERM GOAL OF DEVELOPING A SIMILAR DEVICE FOR MEASUREMENT OF THE TISSUE AVAILABILITY OFA BROAD RANGE OF COMPOUNDS IN BOTH RESEARCH AND MEDICAL SETTINGS. THE DEVICE OPERATES ON THE DIFFUSION-SINK PRIN- CIPLE: A COMPARTMENT IS CREATED IN WHICH THE CONCENTRATION OF THE COMPOUND OF INTEREST IS MAINTAINED AT A NEGLIGIBLE LEVEL, BY ACTION OF A BINDING PROTEIN WITH HIGH AFFINITY ANDSPECIFICITY FOR THAT COMPOUND. CONSEQUENTLY, THE COMPOUND CONTINUOUSLY DIFFUSES INTO THE DEVICE AT A RATE THAT DEPENDSON ITS AVAILABILITY IN THE IMMEDIATE ENVIRONMENT AND THE DIFFUSIVE RESISTANCE OFFERED BY THE WALLS OF THE DEVICE. BYMEASURING THE ACCUMULATION OF A COMPOUND BY A SUBCUTANEOUSLYIMPLANTED DEVICE OVER A SUITABLE TIME INTERVAL, A DIRECT ESTIMATE OF ITS TISSUE AVAILABILITY IS OBTAINED. COMPACT- NESS AND HIGH CAPACITY ARE GAINED BY USING CONCENTRATED BINDING PROTEINS PURIFIED BY AFFINITY CHROMATOGRAPHY. POTENTIAL APPLICATIONS OF THIS DEVICE INCLUDE MEASUREMENT OFTIME-INTEGRATED CORTISOL AVAILABILITY IN CLINICAL PSYCHIATRYFOR DIFFERENTIAL DIAGNOSIS OF ENDOGENOUS DEPRESSION OR MELANCHOLIA.

Principal Investigator:

Stephen E Wade
Principal Investigator
3034995728

Business Contact:

Small Business Information at Submission:

Hammersmith Laboratorytorie
1720 S Marshall Road Suite 50 Boulder, CO 80303

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No